High impact information on Mapk6

• Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3 [1].
• These findings indicate that although the ERK3 kinase is highly specific for ERK3, it does not recognize tyrosine, a feature that distinguishes it from MEKs that phosphorylate other ERK/MAP kinase family members [1].
• This ERK3 kinase phosphorylated a single site on ERK3, Ser189, comparable to Thr183, one of the two activating phosphorylation sites of ERK2 [1].
• Evidence also suggests that PRL stimulates the tyrosyl phosphorylation of ERK-3, a MAP kinase isoform recently identified [2].
• Immunohistochemical double-staining showed that ERK3 expression is restricted to pancreatic beta cells [3].

Biological context of Mapk6

• Transfection with antisense oligonucleotide targeted to ERK3 abolished the insulin secretion stimulated by glucose in rat islets and by PMA in RINm5F cells [3].

Anatomical context of Mapk6

• A specific association of ERK3 with B-Raf in rat hippocampus [4].
• We have previously described that in vitro PRL treatment increases ERK3 expression in isolated rat pancreatic islets [3].

References