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Gene Review

Ecm1  -  extracellular matrix protein 1

Rattus norvegicus

Synonyms: Extracellular matrix protein 1, Secretory component p85
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Disease relevance of Ecm1


Psychiatry related information on Ecm1


High impact information on Ecm1


Chemical compound and disease context of Ecm1


Biological context of Ecm1


Anatomical context of Ecm1


Associations of Ecm1 with chemical compounds


Physical interactions of Ecm1


Enzymatic interactions of Ecm1


Regulatory relationships of Ecm1


Other interactions of Ecm1

  • In contrast, knockdown of Ets-1 in glomeruli resulted in severe ECM deposition in diseased glomeruli [38].
  • In cultures of fetal rat calvarial cells, which form mineralized bonelike nodules, both LTBP and the TGF-beta 1 precursor localized to large fibrillar structures in the extracellular matrix [41].
  • Immunoreactivity for both aFGF and bFGF was positive and similar in the cytoplasm, nuclei, and extracellular matrix of cells of neuroectodermal and mesodermal origin, while it was negative in endoderm-derived cells [42].
  • Reelin (Reln) is a protein with some structural analogies with other extracellular matrix proteins that functions in the regulation of neuronal migration during the development of cortical laminated structures [43].
  • HB-GAM is a secretory, extracellular matrix-associated protein that was isolated by screening for factors that enhance neurite outgrowth in rat brain neurons [44].

Analytical, diagnostic and therapeutic context of Ecm1


  1. Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. Aoki, T., Kataoka, H., Morimoto, M., Nozaki, K., Hashimoto, N. Stroke (2007) [Pubmed]
  2. CD26/dipeptidylpeptidase IV-targeted therapy of acute lung rejection in rats. Jung, F.J., Yang, L., De Meester, I., Augustyns, K., Cardell, M., Hillinger, S., Vogt, P., Lardinois, D., Scharpé, S., Weder, W., Korom, S. J. Heart Lung Transplant. (2006) [Pubmed]
  3. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Border, W.A., Okuda, S., Languino, L.R., Sporn, M.B., Ruoslahti, E. Nature (1990) [Pubmed]
  4. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Cowan, K.N., Heilbut, A., Humpl, T., Lam, C., Ito, S., Rabinovitch, M. Nat. Med. (2000) [Pubmed]
  5. Neuritogenesis induced by thyroid hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase-phosphatidylinositol 3-kinase pathways and involves modulation of extracellular matrix proteins. Martinez, R., Gomes, F.C. J. Biol. Chem. (2002) [Pubmed]
  6. Laminin 1 attenuates beta-amyloid peptide Abeta(1-40) neurotoxicity of cultured fetal rat cortical neurons. Drouet, B., Pinçon-Raymond, M., Chambaz, J., Pillot, T. J. Neurochem. (1999) [Pubmed]
  7. Exercise training attenuates blood pressure elevation and adverse remodeling in the aorta of spontaneously hypertensive rats. Horta, P.P., de Carvalho, J.J., Mandarim-de-Lacerda, C.A. Life Sci. (2005) [Pubmed]
  8. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Etienne-Manneville, S., Hall, A. Cell (2001) [Pubmed]
  9. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Tsujii, M., DuBois, R.N. Cell (1995) [Pubmed]
  10. A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Rossi, P., Karsenty, G., Roberts, A.B., Roche, N.S., Sporn, M.B., de Crombrugghe, B. Cell (1988) [Pubmed]
  11. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Chiquet-Ehrismann, R., Mackie, E.J., Pearson, C.A., Sakakura, T. Cell (1986) [Pubmed]
  12. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. Ashizawa, N., Graf, K., Do, Y.S., Nunohiro, T., Giachelli, C.M., Meehan, W.P., Tuan, T.L., Hsueh, W.A. J. Clin. Invest. (1996) [Pubmed]
  13. Do neurons in the vertebrate CNS migrate on laminin? Liesi, P. EMBO J. (1985) [Pubmed]
  14. Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line. Robinson, J., Viti, M., Höök, M. J. Cell Biol. (1984) [Pubmed]
  15. Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. Sleeman, J., Rudy, W., Hofmann, M., Moll, J., Herrlich, P., Ponta, H. J. Cell Biol. (1996) [Pubmed]
  16. Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. Corman, B., Duriez, M., Poitevin, P., Heudes, D., Bruneval, P., Tedgui, A., Levy, B.I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  17. Carvedilol inhibits platelet-derived growth factor-induced extracellular matrix synthesis by inhibiting cellular reactive oxygen species and mitogen-activated protein kinase activation. Park, J., Ha, H., Kim, M.S., Ahn, H.J., Huh, K.H., Kim, Y.S. J. Heart Lung Transplant. (2006) [Pubmed]
  18. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Chiang, C.K., Sheu, M.L., Hung, K.Y., Wu, K.D., Liu, S.H. Kidney Int. (2006) [Pubmed]
  19. Increase in extracellular cross-linking by tissue transglutaminase and reduction in expression of MMP-9 contribute differentially to focal segmental glomerulosclerosis in rats. Liu, S., Li, Y., Zhao, H., Chen, D., Huang, Q., Wang, S., Zou, W., Zhang, Y., Li, X., Huang, H. Mol. Cell. Biochem. (2006) [Pubmed]
  20. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. Machado, L.S., Kozak, A., Ergul, A., Hess, D.C., Borlongan, C.V., Fagan, S.C. BMC neuroscience [electronic resource]. (2006) [Pubmed]
  21. Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilage. Bhalerao, J., Tylzanowski, P., Filie, J.D., Kozak, C.A., Merregaert, J. J. Biol. Chem. (1995) [Pubmed]
  22. Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution. Manase, K., Endo, T., Chida, M., Nagasawa, K., Honnma, H., Yamazaki, K., Kitajima, Y., Goto, T., Kanaya, M., Hayashi, T., Mitaka, T., Saito, T. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  23. Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase. Naparstek, Y., Cohen, I.R., Fuks, Z., Vlodavsky, I. Nature (1984) [Pubmed]
  24. Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Sata, M., Saiura, A., Kunisato, A., Tojo, A., Okada, S., Tokuhisa, T., Hirai, H., Makuuchi, M., Hirata, Y., Nagai, R. Nat. Med. (2002) [Pubmed]
  25. Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Moos, M., Tacke, R., Scherer, H., Teplow, D., Früh, K., Schachner, M. Nature (1988) [Pubmed]
  26. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison, H., Sherman, L.S., Legg, J., Banine, F., Isacke, C., Haipek, C.A., Gutmann, D.H., Ponta, H., Herrlich, P. Genes Dev. (2001) [Pubmed]
  27. Alpha 6 integrins are required for Langerhans cell migration from the epidermis. Price, A.A., Cumberbatch, M., Kimber, I., Ager, A. J. Exp. Med. (1997) [Pubmed]
  28. Overlap of IGF- and heparin-binding sites in rat IGF-binding protein-5. Song, H., Beattie, J., Campbell, I.W., Allan, G.J. J. Mol. Endocrinol. (2000) [Pubmed]
  29. Transcriptional up-regulation of endothelial cell matrix metalloproteinase-2 in response to extracellular cues involves GATA-2. Han, X., Boyd, P.J., Colgan, S., Madri, J.A., Haas, T.L. J. Biol. Chem. (2003) [Pubmed]
  30. A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. Viapiano, M.S., Matthews, R.T., Hockfield, S. J. Biol. Chem. (2003) [Pubmed]
  31. The first stage of transforming growth factor beta1 activation is release of the large latent complex from the extracellular matrix of growth plate chondrocytes by matrix vesicle stromelysin-1 (MMP-3). Maeda, S., Dean, D.D., Gomez, R., Schwartz, Z., Boyan, B.D. Calcif. Tissue Int. (2002) [Pubmed]
  32. The entering of indium-111 and iron-59 into the hepatocytes from partially hepatectomized rats differ from that of gallium-67. Sato, R., Abe, S., Yamada, Y., Toyama, D., Ohtake, Y., Sato, N., Ohkubo, Y. Biol. Pharm. Bull. (2004) [Pubmed]
  33. Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. Bockholt, S.M., Burridge, K. J. Biol. Chem. (1993) [Pubmed]
  34. Cell/substratum adhesions in RSV-transformed rat fibroblasts. Nermut, M.V., Eason, P., Hirst, E.M., Kellie, S. Exp. Cell Res. (1991) [Pubmed]
  35. Lysyl oxidase, the extracellular matrix-forming enzyme, in rat brain injury sites. Gilad, G.M., Kagan, H.M., Gilad, V.H. Neurosci. Lett. (2001) [Pubmed]
  36. Syk and paxillin are differentially phosphorylated following adhesion to the plastic substrate in rat alveolar macrophages. Hirano, S., Kanno, S. Immunology (1999) [Pubmed]
  37. Organization of functional domains in the docking protein p130Cas. Nasertorabi, F., Garcia-Guzman, M., Briknarová, K., Larsen, E., Havert, M.L., Vuori, K., Ely, K.R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  38. Transcription factor Ets-1 is essential for mesangial matrix remodeling. Mizui, M., Isaka, Y., Takabatake, Y., Sato, Y., Kawachi, H., Shimizu, F., Takahara, S., Ito, T., Imai, E. Kidney Int. (2006) [Pubmed]
  39. Increased MMP-2 expression in connective tissue growth factor over-expression vascular smooth muscle cells. Fan, W.H., Karnovsky, M.J. J. Biol. Chem. (2002) [Pubmed]
  40. Modulation of transforming growth factor beta function in hepatocytes and hepatic stellate cells in rat liver injury. Date, M., Matsuzaki, K., Matsushita, M., Tahashi, Y., Furukawa, F., Inoue, K. Gut (2000) [Pubmed]
  41. Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. Dallas, S.L., Miyazono, K., Skerry, T.M., Mundy, G.R., Bonewald, L.F. J. Cell Biol. (1995) [Pubmed]
  42. Acidic fibroblast growth factor in the developing rat embryo. Fu, Y.M., Spirito, P., Yu, Z.X., Biro, S., Sasse, J., Lei, J., Ferrans, V.J., Epstein, S.E., Casscells, W. J. Cell Biol. (1991) [Pubmed]
  43. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Pesold, C., Liu, W.S., Guidotti, A., Costa, E., Caruncho, H.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  44. HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts. Rauvala, H., Peng, H.B. Prog. Neurobiol. (1997) [Pubmed]
  45. Expression of fibronectin and laminin in the rat liver after partial hepatectomy, during carcinogenesis, and in transplantable hepatocellular carcinomas. Sell, S., Ruoslahti, E. J. Natl. Cancer Inst. (1982) [Pubmed]
  46. Solubilization and degradation of extracellular matrix by various metastatic cell lines derived from a rat rhabdomyosarcoma. Becker, M., Moczar, M., Poupon, M.F., Moczar, E. J. Natl. Cancer Inst. (1986) [Pubmed]
  47. Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver. Kumaran, V., Joseph, B., Benten, D., Gupta, S. Gastroenterology (2005) [Pubmed]
  48. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Lugea, A., Gukovsky, I., Gukovskaya, A.S., Pandol, S.J. Gastroenterology (2003) [Pubmed]
  49. Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokines. Ramadori, G., Knittel, T., Odenthal, M., Schwögler, S., Neubauer, K., Meyer zum Büschenfelde, K.H. Gastroenterology (1992) [Pubmed]
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