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Gene Review

PAPPA2  -  pappalysin 2

Homo sapiens

Synonyms: PAPP-A2, PAPP-E, PAPPE, PLAC3, Pappalysin-2, ...
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Disease relevance of PAPPA2


High impact information on PAPPA2

  • Except for PAPP-A2, PAPP-A does not share global similarity with other proteins [2].
  • We showed that PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144 [3].
  • Because PAPP-A specifically cleaves insulin-like growth factor-binding protein (IGFBP)-4, one of six known modulators of IGF-I and -II, we looked for a possible PAPP-A2 substrate among the members of this family [3].
  • This explains, at least in part, why PAPP-A2 lacks the ability of cell surface adhesion, and further emphasizes the role of the basic clusters defined in PAPP-A [4].
  • In addition, new alternative spliced mRNAs were detected for IK, TRAP240 and PLAC3 genes [5].

Biological context of PAPPA2

  • Gene structure analysis revealed that PAPP-E was encoded on 23 exons on chromosome 1 and its splice variant on the first five same exons [1].
  • The PAPP-E gene was localized to chromosome 1q23-25 [6].
  • We present evidence that a protein domain with weak similarity to known laminin G-like (LG) modules is contained within this region, and we propose that PAPP-A and PAPP-A2 are new and unique members in the group of LG proteins as the pappalysins represent the first examples where LG modules are associated with proteinases [7].

Anatomical context of PAPPA2

  • Both PAPP-E variants were found to be co-expressed abundantly in the placenta and non-pregnant mammary gland with low expression in the kidney, foetal brain and pancreas [1].

Other interactions of PAPPA2


Analytical, diagnostic and therapeutic context of PAPPA2


  1. The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. Page, N.M., Butlin, D.J., Lomthaisong, K., Lowry, P.J. Placenta (2001) [Pubmed]
  2. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. Overgaard, M.T., Sorensen, E.S., Stachowiak, D., Boldt, H.B., Kristensen, L., Sottrup-Jensen, L., Oxvig, C. J. Biol. Chem. (2003) [Pubmed]
  3. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. Overgaard, M.T., Boldt, H.B., Laursen, L.S., Sottrup-Jensen, L., Conover, C.A., Oxvig, C. J. Biol. Chem. (2001) [Pubmed]
  4. Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module. Weyer, K., Overgaard, M.T., Laursen, L.S., Nielsen, C.G., Schmitz, A., Christiansen, M., Sottrup-Jensen, L., Giudice, L.C., Oxvig, C. Eur. J. Biochem. (2004) [Pubmed]
  5. Differential display RT-PCR analysis of human choriocarcinoma cell lines and normal term trophoblast cells: identification of new genes expressed in placenta. García, J., Castrillo, J.L. Placenta (2004) [Pubmed]
  6. Pregnancy-associated plasma protein-E (PAPP-E). Farr, M., Strübe, J., Geppert, H.G., Kocourek, A., Mahne, M., Tschesche, H. Biochim. Biophys. Acta (2000) [Pubmed]
  7. Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules. Boldt, H.B., Glerup, S., Overgaard, M.T., Sottrup-Jensen, L., Oxvig, C. Protein Expr. Purif. (2006) [Pubmed]
  8. Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats. Laursen, L.S., Overgaard, M.T., Weyer, K., Boldt, H.B., Ebbesen, P., Christiansen, M., Sottrup-Jensen, L., Giudice, L.C., Oxvig, C. J. Biol. Chem. (2002) [Pubmed]
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