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Gene Review

RPL29  -  ribosomal protein L29

Homo sapiens

Synonyms: 60S ribosomal protein L29, Cell surface heparin-binding protein HIP, HIP, HUMRPL29, L29, ...
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Disease relevance of RPL29


High impact information on RPL29

  • Inducing differentiation by dominant-negative inhibition of the beta-catenin/Tcf-4 complexes in LS174T cells also resulted in downregulation of HIP/RPL29 [1].
  • Inducing cellular differentiation in HT-29 cells by both sodium butyrate and glucose deprivation resulted in a significant downregulation of HIP/RPL29 expression [1].
  • The resultant knockdown of HIP/RPL29 expression induced cellular differentiation, as shown by the increased expression of two known markers of differentiation in LS174T cells, galectin-4 and mucin-2 [1].
  • We also found that these two genes are linked on a macronuclear chromosome, similarly arranged tail to tail, in the three spirotrichs Stylonychia lemnae, Uroleptus sp., and Holosticha sp.. In addition, single-gene macronuclear chromosomes containing only the RPL29 gene were detected in the earlier diverged Holosticha and Uroleptus [2].
  • These data will provide valuable tools to progress the understanding of HIP/RPL29 function as a ribosomal protein and/or as a regulator of growth and cell adhesion through interaction with heparan sulfate proteoglycans [3].

Chemical compound and disease context of RPL29


Biological context of RPL29


Anatomical context of RPL29


Associations of RPL29 with chemical compounds

  • A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin [6].

Other interactions of RPL29

  • Of the human ribosomal protein genes mapped, RPL29 is the shortest distance from another ribosomal protein gene marker, RPL35 a which has also been mapped to the 3q29-qter region [4].


  1. Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. Liu, J.J., Huang, B.H., Zhang, J., Carson, D.D., Hooi, S.C. J. Cell. Physiol. (2006) [Pubmed]
  2. Conserved linkage of two genes on the same macronuclear chromosome in spirotrichous ciliates. McFarland, C.P., Chang, W.J., Kuo, S., Landweber, L.F. Chromosoma (2006) [Pubmed]
  3. Cloning, expression, and chromosome mapping of the murine Hip/Rpl29 gene. Kirn-Safran, C.B., Dayal, S., Martin-DeLeon, P.A., Carson, D.D. Genomics (2000) [Pubmed]
  4. Mapping of the human ribosomal large subunit protein gene RPL29 to human chromosome 3q29-qter. Garcia-Barcelo, M., Law, P.T., Tsui, S.K., Fung, K.P., Lee, C.Y., Waye, M.M. Genomics (1997) [Pubmed]
  5. A novel cDNA encoding a human homologue of ribosomal protein L29. Law, P.T., Tsui, S.K., Lam, W.Y., Luk, S.C., Hwang, D.M., Liew, C.C., Lee, C.Y., Fung, K.P., Waye, M.M. Biochim. Biophys. Acta (1996) [Pubmed]
  6. A heparin binding synthetic peptide from human HIP / RPL29 fails to specifically differentiate between anticoagulantly active and inactive species of heparin. Hoke, D.E., Carson, D.D., Höök, M. Journal of negative results in biomedicine [electronic resource]. (2003) [Pubmed]
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