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Gene Review

RPL32  -  ribosomal protein L32

Homo sapiens

Synonyms: 60S ribosomal protein L32, L32, PP9932
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High impact information on RPL32


Biological context of RPL32

  • Three nuclear polypeptides of approximately 18, 28, and 50 kD that bind to the rpL32 promoter region (-24.+11) have been detected in HeLa cells by ligand blotting [5].

Anatomical context of RPL32

  • DNA-protein complex formation between the investigated rpL32 promoter fragment containing the GCC-element and human fibroblast nuclear proteins is Zn2+-dependent [5].
  • The method of functional titration (in vivo competition in the CAT-test) revealed that the GCC-element within the rpL32 promoter functions as a positive cis-acting transcriptional element in NIH 3T3 cells [5].


  1. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. Young, J.A., Trowsdale, J. Nucleic Acids Res. (1985) [Pubmed]
  2. Stability of housekeeping genes in alveolar macrophages from COPD patients. Ishii, T., Wallace, A.M., Zhang, X., Gosselink, J., Abboud, R.T., English, J.C., Paré, P.D., Sandford, A.J. Eur. Respir. J. (2006) [Pubmed]
  3. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. Vorobieva, N.V., Filipenko, M.L., Karpova, G.G., Mertvetsov, N.P., Graphodatsky, A.S. Cytogenet. Cell Genet. (1997) [Pubmed]
  4. Two C or not two C: recurrent disruption of Zn-ribbons, gene duplication, lineage-specific gene loss, and horizontal gene transfer in evolution of bacterial ribosomal proteins. Makarova, K.S., Ponomarev, V.A., Koonin, E.V. Genome Biol. (2001) [Pubmed]
  5. DNA-protein interactions between mammalian nuclear proteins and a GCC-element included in a composite cis-acting element of mouse ribosomal protein L32 promoter. Orlov, S.V., Kuteikin, K.B., Dizhe, E.B., Kuryshev, V.Y., Shpakovich, V.M., Perevozchikov, A.P. Biochemistry Mosc. (1999) [Pubmed]
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