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Gene Review

SCNN1D  -  sodium channel, non voltage gated 1 delta...

Homo sapiens

Synonyms: Amiloride-sensitive sodium channel subunit delta, DNACH, Delta-ENaC, Delta-NaCH, ENaCD, ...
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High impact information on SCNN1D


Biological context of SCNN1D

  • To explain this discrepancy, we searched for novel functional properties of homomeric ENaCdelta and investigated the detailed tissue distribution in humans [3].

Anatomical context of SCNN1D

  • When human ENaCdelta was expressed in Xenopus oocytes and Chinese hamster ovary cells, a reduction of extracellular pH activated this channel (half-maximal pH for an activation of 5.0), and the acid-induced current was abolished by amiloride [3].
  • RNA dot-blot analyses showed that ENaCdelta mRNA was widely distributed throughout the brain and was also expressed in the heart, kidney, and pancreas in humans [3].
  • Northern blotting confirmed that ENaCdelta was expressed in the cerebellum and the hippocampus [3].

Analytical, diagnostic and therapeutic context of SCNN1D


  1. Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. Ji, H.L., Su, X.F., Kedar, S., Li, J., Barbry, P., Smith, P.R., Matalon, S., Benos, D.J. J. Biol. Chem. (2006) [Pubmed]
  2. Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel. Yamamura, H., Ugawa, S., Ueda, T., Nagao, M., Shimada, S. J. Biol. Chem. (2004) [Pubmed]
  3. Protons activate the delta-subunit of the epithelial Na+ channel in humans. Yamamura, H., Ugawa, S., Ueda, T., Nagao, M., Shimada, S. J. Biol. Chem. (2004) [Pubmed]
  4. Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel. Ji, H.L., Benos, D.J. J. Biol. Chem. (2004) [Pubmed]
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