The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

RNF123  -  ring finger protein 123

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF123, FLJ12565, FP1477, KPC1, Kip1 ubiquitination-promoting complex protein 1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of RNF123

 

High impact information on RNF123

  • Depletion of KPC1 by RNA interference also inhibited p27(Kip1) degradation [2].
  • These observations suggest that KPC2 cooperatively regulates p27 degradation with KPC1 and that the STI1 domain as well as the UBL and UBA domains of KPC2 are indispensable for its function [3].
  • The KPC-2-producing isolates were either susceptible or intermediate to imipenem and meropenem, unlike the KPC-1-producing isolate, which was resistant to these agents [4].
  • Finally, a few Ambler class A (SME-1, NMC-A, IMI-1, KPC-1) and class D (OXA-23 to -27) beta-lactamases involved in carbapenem hydrolysis have been reported also from rare isolates of Gram-negative rods [5].

References

  1. Emerging carbapenemases in Gram-negative aerobes. Nordmann, P., Poirel, L. Clin. Microbiol. Infect. (2002) [Pubmed]
  2. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I. Nat. Cell Biol. (2004) [Pubmed]
  3. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N., Nakayama, K.I. Mol. Cell. Biol. (2005) [Pubmed]
  4. Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates. Smith Moland, E., Hanson, N.D., Herrera, V.L., Black, J.A., Lockhart, T.J., Hossain, A., Johnson, J.A., Goering, R.V., Thomson, K.S. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support. Poirel, L., Nordmann, P. Current pharmaceutical biotechnology. (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities