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Gene Review

RNF123  -  ring finger protein 123

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF123, FLJ12565, FP1477, KPC1, Kip1 ubiquitination-promoting complex protein 1, ...
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Disease relevance of RNF123


High impact information on RNF123

  • Depletion of KPC1 by RNA interference also inhibited p27(Kip1) degradation [2].
  • These observations suggest that KPC2 cooperatively regulates p27 degradation with KPC1 and that the STI1 domain as well as the UBL and UBA domains of KPC2 are indispensable for its function [3].
  • The KPC-2-producing isolates were either susceptible or intermediate to imipenem and meropenem, unlike the KPC-1-producing isolate, which was resistant to these agents [4].
  • Finally, a few Ambler class A (SME-1, NMC-A, IMI-1, KPC-1) and class D (OXA-23 to -27) beta-lactamases involved in carbapenem hydrolysis have been reported also from rare isolates of Gram-negative rods [5].


  1. Emerging carbapenemases in Gram-negative aerobes. Nordmann, P., Poirel, L. Clin. Microbiol. Infect. (2002) [Pubmed]
  2. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., Nakayama, K.I. Nat. Cell Biol. (2004) [Pubmed]
  3. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. Hara, T., Kamura, T., Kotoshiba, S., Takahashi, H., Fujiwara, K., Onoyama, I., Shirakawa, M., Mizushima, N., Nakayama, K.I. Mol. Cell. Biol. (2005) [Pubmed]
  4. Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates. Smith Moland, E., Hanson, N.D., Herrera, V.L., Black, J.A., Lockhart, T.J., Hossain, A., Johnson, J.A., Goering, R.V., Thomson, K.S. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support. Poirel, L., Nordmann, P. Current pharmaceutical biotechnology. (2002) [Pubmed]
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