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Gene Review

CARD9  -  caspase recruitment domain family, member 9

Homo sapiens

Synonyms: CANDF2, Caspase recruitment domain-containing protein 9, hCARD9
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Disease relevance of CARD9

  • The positive rates for CARD9, Bcl10, and API2-MALT1 chimeric transcript in the lymphoma patients were 48%, 98%, and 8%, respectively, whereas the 3 molecules were not detected in any specimens from patients with chronic gastritis [1].
  • The expression of CARMA1 and CARD9 was frequent in the Helicobacter pylori-negative patients (100% and 86%, respectively), in the API2-MALT1 chimeric transcript-positive patients (100% and 100%, respectively), and in the specimens from patients who did not respond to H. pylori eradication (76% and 71%, respectively) [1].
  • CARD9-deficient mice failed to clear infection and showed altered cytokine production after challenge with Listeria monocytogenes [2].

High impact information on CARD9

  • Our data demonstrate that CARD9 has a critical function in Nod2-mediated activation of p38 and Jnk in innate immune responses to intracellular pathogens [2].
  • Furthermore, endogenous CARD9 is found associated with BCL10 suggesting that both proteins form a pre-existing signaling complex within cells [3].
  • Interphase fluorescent in situ hybridisation confirmed genomic gain of the TRAF2, CARD9 and MALT1 loci in 5/6 and 2/2 cases showing chromosomal gains at 9q34 and 18q21 respectively [4].
  • CONCLUSIONS: The overexpression of CARMA1 and CARD9 presumably is associated with the development or progression of gastric B-cell lymphoma, especially among patients who have disease in which the pathogenesis is not related to H. pylori [1].

Physical interactions of CARD9

  • To identify upstream signaling partners of BCL10, we performed a mammalian two-hybrid analysis and identified CARD9 as a novel CARD-containing protein that interacts selectively with the CARD activation domain of BCL10 [3].

Analytical, diagnostic and therapeutic context of CARD9


  1. Overexpression of caspase recruitment domain (CARD) membrane-associated guanylate kinase 1 (CARMA1) and CARD9 in primary gastric B-cell lymphoma. Nakamura, S., Nakamura, S., Matsumoto, T., Yada, S., Hirahashi, M., Suekane, H., Yao, T., Goda, K., Iida, M. Cancer (2005) [Pubmed]
  2. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Hsu, Y.M., Zhang, Y., You, Y., Wang, D., Li, H., Duramad, O., Qin, X.F., Dong, C., Lin, X. Nat. Immunol. (2007) [Pubmed]
  3. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. Bertin, J., Guo, Y., Wang, L., Srinivasula, S.M., Jacobson, M.D., Poyet, J.L., Merriam, S., Du, M.Q., Dyer, M.J., Robison, K.E., DiStefano, P.S., Alnemri, E.S. J. Biol. Chem. (2000) [Pubmed]
  4. Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21). Zhou, Y., Ye, H., Martin-Subero, J.I., Hamoudi, R., Lu, Y.J., Wang, R., Siebert, R., Shipley, J., Isaacson, P.G., Dogan, A., Du, M.Q. Br. J. Haematol. (2006) [Pubmed]
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