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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EDDM3B  -  epididymal protein 3B

Homo sapiens

Synonyms: EP3B, Epididymal secretory protein E3-beta, FAM12B, HE3-BETA, HE3-beta, ...
 
 
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High impact information on FAM12B

  • alpha 1-Acid glycoprotein (AGP) was purified to homogeneity by a 3-step procedure using pseudo-ligand affinity chromatography on immobilized Cibacron blue F3GA, Procion red HE3B, and preparative column isoelectric focusing [1].
  • More detailed sequence and PCR analysis identified two different but homologous gene transcripts, HE3 alpha and HE3 beta [2].
  • Although genomic clones corresponding to HE3 beta could not be found, a third highly homologous gene, HE3 gamma, was identified as a potential pseudogene [2].
  • The dye Procion Red HE3B immobilized on agarose and available as Matrex Gel Red A is shown to bind citrate synthase and succinate thiokinase from a number of diverse organisms [3].
  • Inactivation of wheat-germ aspartate transcarbamoylase by the triazinyl dye, procion red HE3B [4].
 

Associations of FAM12B with chemical compounds

References

  1. A three-step purification of human alpha 1-acid glycoprotein. Laurent, P., Miribel, L., Bienvenu, J., Vallve, C., Arnaud, P. FEBS Lett. (1984) [Pubmed]
  2. Major human epididymis-specific gene product, HE3, is the first representative of a novel gene family. Kirchhoff, C., Pera, I., Rust, W., Ivell, R. Mol. Reprod. Dev. (1994) [Pubmed]
  3. Affinity chromatography of acyl-CoA utilizing enzymes on Procion Red-agarose. Weitzman, P.D., Ridley, J. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  4. Inactivation of wheat-germ aspartate transcarbamoylase by the triazinyl dye, procion red HE3B. Easton, M.J., Yon, R.J. Biochim. Biophys. Acta (1992) [Pubmed]
  5. Interaction of ferredoxin-NADP+ oxidoreductase with triazine dyes. A rapid purification method by affinity chromatography. Carrillo, N., Vallejos, R.H. Biochim. Biophys. Acta (1983) [Pubmed]
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