Disease relevance of triazine

• However, the triazine-resistant mutant T4 from Rhodopseudomonas (Rps.) viridis, which has the tyrosine residue at position 222 on the L subunit substituted for phenylalanine (TyrL222Phe), is sensitive to both ureas and phenolics [1].
• Immunogenicity and protective efficacy of Bacillus anthracis poly-gamma-D-glutamic acid capsule covalently coupled to a protein carrier using a novel triazine-based conjugation strategy [2].
• Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism [3].
• Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli [4].
• A triazine dye, cibacron blue F3GA, decreases oxacillin resistance levels in methicillin-resistant Staphylococcus aureus [5].

High impact information on triazine

• The optimum lipophilicity (pi 0) of triazine substituents for purified L1210 dihydrofolate reductase is 1.76 to 2.11; for sensitive cells, it is 1.45 to 1.83, and for resistant cells, it is approximately 6 [6].
• Triazinate (TZT), a triazine folate antagonist, is a potent inhibitor of dihydrofolate reductase from mammalian cells [7].
• Ligand 12459, a potent G-quadruplex ligand that belongs to the triazine series, has been previously shown to induce both telomere shortening and apoptosis in the human A549 cell line as a function of its concentration and time exposure [8].
• The high quality of the electron density maps also allowed a reliable discussion of the mode of binding of the triazine herbicide terbutryn at the binding site of the secondary quinone, Q(B) [9].
• Similarly, triazine dye-ligand chromatography demonstrated coisolation of p47phox and p67phox [10].

Chemical compound and disease context of triazine

• All the experiments were done on either triazine inhibition of pure DHFR from L1210 leukemia cells and on the inhibition of intact L1210 leukemia cells sensitive and resistant to methotrexate or on steroid binding to progesterone [11].
• The flow immunoassay was developed using the triazine herbicide atrazine as a model compound owing to its human toxicity and widespread use [12].
• A triazine dye, Cibacron blue 3G-A (CB), is an inhibitor of cell separation of staphylococcal spp. therefore, we examined the effect of CB on growth of gram-positive bacteria other than Staphylococcus [13].
• Acinetobacter species was also active on other triazine pesticides, viz., simazine, terbutryn, cyanazine, and prometon [14].
• Glucose dehydrogenase (EC 1.1.1.47) from Bacillus subtilis was purified about 5240-fold, using an aqueous two-phase system and triazine-dye affinity chromatography [15].

Biological context of triazine

• After the incorporation of 5-azacytidine-5'-phosphate into a polynucleotide chain the rate of hydrolysis of the triazine ring decreases considerably [16].
• Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening [17].
• We have shuffled two highly homologous triazine hydrolases and conducted an exploration of the substrate specificities of the resulting enzymes to acquire a better understanding of the possible distributions of novel functions in sequence space [18].
• The QSAR for the quinazolines is compared with QSAR for triazine and pyrimidine inhibitors [19].
• The terminal biomimetic moiety bore a carboxyl or a keto acid structure linked to the triazine ring, thus mimicking the substrate of MDH [20].

Anatomical context of triazine

• A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening [21].
• A triazine-based combinatorial library of small molecules was screened in albino murine melanocytes to identify compounds that induce pigmentation [3].
• Triazine monomers and their adhesion to dentin [22].
• The high affinity of these synthetic affinity membranes to triazine herbicides together with their straightforward and inexpensive preparation provides a good basis for the development of applications of imprinted polymers in separation processes such as solid-phase extraction [23].
• Fractionation of the ribosome inactivating protein preparations with triazine dyes [24].

Associations of triazine with other chemical compounds

• X-ray structural results are reported for 10 triazine and pyrimidine inhibitors of dihydrofolate reductase, each one studied as a ternary complex with NADPH and chicken dihydrofolate reductase [25].
• Metal-ion-promoted binding of triazine dyes to proteins. The interaction of Cibacron Blue F3G-A with yeast hexokinase [26].
• 3-Hydroxybutyrate dehydrogenase (EC 1.1.1.30) and malate dehydrogenase (EC 1.1.1.37) were purified to homogeneity on a large scale involving only two sequential affinity-chromatography steps on two triazine dye-Sepharose matrices [27].
• A series of 70 triazine derivatives have been synthesized and tested for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity [28].
• Dinoseb is a herbicide known to inhibit photosystem II electron transfer like DCMU, triazine and phenolic-type herbicides [29].

Gene context of triazine

• New triazine derivatives as potent modulators of multidrug resistance [28].
• These findings together with other reports indicate that the estrogenic effects associated with the triazine herbicides in vivo are not estrogen receptor-mediated, but may be explained partly by their ability to induce aromatase in vitro [30].
• Ligand 12459, a potent G-quadruplex-interacting agent that belongs to the triazine series, was previously shown to downregulate telomerase activity in the human A549 lung carcinoma cell line [31].
• 1. A number of reactive triazine dyes specifically and irreversibly inactive yeast hexokinase at pH 8.5 and 33 degrees C. Under these conditions, the enzyme is readily inactivated by 100 microM-Procion Green H-4G, Blue H-B, Turquoise H-7G and Turquoise H-A, is less readily inactivated by Procion Brown H-2G [32].
• Estrogen receptor purification by affinity chromatography using an orange triazine dye [33].

Analytical, diagnostic and therapeutic context of triazine

• A review of epidemiologic studies of triazine herbicides and cancer [34].
• Malate dehydrogenase could also be purified by a combination of triazine dye affinity chromatography and gel filtration on Ultrogel AcA-44, but this offered no significant advantage over the purely affinity procedure [27].
• In the present work, a study is reported of the potential of coupled-column liquid chromatography (LC) applied to the determination of triazine residues in environmental water samples [35].
• Enzyme-linked immunosorbent assay compared with gas chromatography/mass spectrometry for the determination of triazine herbicides in water [36].
• The combination of screening analysis by ELISA, which requires no sample preparation and works on 160 microL of sample, and confirmation by GC/MS was designed for rapid, inexpensive analysis of triazine herbicides in water [36].

References