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Chemical Compound Review

Cibacron Blue     1-amino-4-[[4-[[4-chloro-6- [(2...

Synonyms: CHEMBL572528, AG-L-65229, CHEBI:47301, CHEBI:672706, C9534_SIAL, ...
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Disease relevance of AIDS081430


High impact information on AIDS081430


Chemical compound and disease context of AIDS081430


Biological context of AIDS081430


Anatomical context of AIDS081430

  • The binding of estradiol--receptor complexes of mouse uterine cytosol to oligodeoxynucleotide celluloses is inhibited by the sulfonated polyaromatic dye Cibacron blue F3GA [10].
  • Chicken stomach membranes were solubilized in digitonin, glycoproteins were separated from solubilized proteins by lectin chromatography, and nucleotide-binding glycoproteins were selected by immobilized Cibacron blue chromatography [20].
  • Incubation of microsomes with trypsin prior to enzyme extraction resulted in a 50% inactivation of the fatty acyltransferase and generation of 53- and 55-kDa protein bands, which also had affinity to Cibacron blue F3GA and were displaced from the column together with the active (intact) enzyme [21].
  • Thus, in contrast to pepsinogen, the acid-induced reversible conformational change is not followed by autocatalysis. pRa of amniotic fluid and plasma could be separated from R by affinity chromatography on Cibacron blue F3GA-agarose, and R but not pRa was detected by an immunoassay using monoclonal antibodies reacting with R and not with pR [22].
  • Studies on the kinetic sequence of in vitro ribosome assembly using cibacron blue F3GA as a general assembly inhibitor [23].

Associations of AIDS081430 with other chemical compounds


Gene context of AIDS081430

  • H. pylori TR was purified to homogeneity by chromatography on DEAE-52, Cibacron blue 3GA, and 2',5'-ADP-agarose [29].
  • Using a primary monolayer culture system, we investigated the proliferative activity of human (h) cord blood (CB) and highly purified AFP. hAFP, purified from hCB by Cibacron blue and immunoaffinity chromatography was homogeneous on SDS-PAGE and silver stain [30].
  • Like other GSTs, chicken PGDS was found to be inhibited by non-substrate ligands such as Cibacron Blue, haematin and organotin compounds [31].
  • The individual subunits did not interact with Cibacron Blue F3G-A, a biomimetic ligand of phosphofructokinase-1 [32].
  • To overcome these difficulties the stabilizing effect of the dye Cibacron blue 3GA on AR and estrogen receptor (ER) proteins, and its ability to bind to these proteins, was utilized in developing an assay system for each receptor that could be applied to small samples [33].

Analytical, diagnostic and therapeutic context of AIDS081430


  1. Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Bestor, T.H., Ingram, V.M. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Purification of receptor protein Trg by exploiting a property common to chemotactic transducers of Escherichia coli. Burrows, G.G., Newcomer, M.E., Hazelbauer, G.L. J. Biol. Chem. (1989) [Pubmed]
  3. Dihydrofolate reductases from chicken liver and Lactobacillus casei bind Cibacron blue F3GA in different modes and at different sites. Subramanian, S., Kaufman, B.T. J. Biol. Chem. (1980) [Pubmed]
  4. Inhibition of Azotobacter vinelandii RNA polymerase by cibacron blue F3GA. Kumar, S.A., Krakow, J.S. J. Biol. Chem. (1977) [Pubmed]
  5. The effect of ligand presaturation on the interaction of serum albumins with an immobilized Cibacron Blue 3G-A studied by affinity gel electrophoresis. Metcalf, E.C., Crow, B., Dean, P.D. Biochem. J. (1981) [Pubmed]
  6. Characterization of inactive renin from human kidney and plasma. Evidence of a renal source of circulating inactive renin. Hsueh, W.A., Carlson, E.J., Dzau, V.J. J. Clin. Invest. (1983) [Pubmed]
  7. Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems. Higgins, C.F., Hiles, I.D., Whalley, K., Jamieson, D.J. EMBO J. (1985) [Pubmed]
  8. Unusual apparently constitutive interferons and antagonists in human placental blood. Duc-Goiran, P., Robert-Galliot, B., Lopez, J., Chany, C. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  9. Specificity of oligodeoxynucleotide binding of mouse uterine cytosol estradiol receptors. Kumar, S.A., Beach, T.A., Dickerman, H.W. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Effect of Cibacron blue F3GA on oligonucleotide binding site of estradiol--receptor complexes of mouse uterine cytosol. Kumar, S.A., Beach, T.A., Dickerman, H.W. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  11. Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones. Volonté, C., Ciotti, M.T., D'Ambrosi, N., Lockhart, B., Spedding, M. Neuropharmacology (1999) [Pubmed]
  12. Limonoate dehydrogenase from Arthrobacter globiformis: the native enzyme and its N-terminal sequence. Suhayda, C.G., Omura, M., Hasegawa, S. Phytochemistry (1995) [Pubmed]
  13. Binding of hepatitis virus particles to immobilised procion blue-HB and cibacron blue 3GA. Brown, R.A., Combridge, B.S. J. Virol. Methods (1986) [Pubmed]
  14. Non-linear slow-binding inhibition of Aerococcus viridans lactate oxidase by Cibacron Blue 3GA. Streitenberger, S.A., López-Mas, J.A., Sánchez-Ferrer, A., García-Carmona, F. J. Enzym. Inhib. (2001) [Pubmed]
  15. On the regulation of K+ uniport in intact mitochondria by adenine nucleotides and nucleotide analogs. Beavis, A.D., Lu, Y., Garlid, K.D. J. Biol. Chem. (1993) [Pubmed]
  16. Adenosine cyclic 3',5'-monophosphate dependent protein kinase: active site directed inhibition by Cibacron Blue F3GA. Witt, J.J., Roskoski, R. Biochemistry (1980) [Pubmed]
  17. Diffusion-enhanced energy transfer shows accessibility of ribonucleic acid polymerase inhibitor binding sites. Meares, C.F., Rice, L.S. Biochemistry (1981) [Pubmed]
  18. P2x-purinoceptors of myenteric neurones from the guinea-pig ileum and their unusual pharmacological properties. Barajas-López, C., Huizinga, J.D., Collins, S.M., Gerzanich, V., Espinosa-Luna, R., Peres, A.L. Br. J. Pharmacol. (1996) [Pubmed]
  19. Role of adenosine triphosphate and adenosine in oxygen-induced pulmonary vasodilation in fetal lambs. Konduri, G.G., Gervasio, C.T., Theodorou, A.A. Pediatr. Res. (1993) [Pubmed]
  20. Immunolocalization of the ecto-ATPase and ecto-apyrase in chicken gizzard and stomach. Purification and N-terminal sequence of the stomach ecto-apyrase. Lewis-Carl, S., Kirley, T.L. J. Biol. Chem. (1997) [Pubmed]
  21. Purification of protein fatty acyltransferase and determination of its distribution and topology. Kasinathan, C., Grzelinska, E., Okazaki, K., Slomiany, B.L., Slomiany, A. J. Biol. Chem. (1990) [Pubmed]
  22. Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin. Derkx, F.H., Schalekamp, M.P., Schalekamp, M.A. J. Biol. Chem. (1987) [Pubmed]
  23. Studies on the kinetic sequence of in vitro ribosome assembly using cibacron blue F3GA as a general assembly inhibitor. Datta, D., Changchien, L.M., Craven, G.R. Nucleic Acids Res. (1986) [Pubmed]
  24. Purification from bovine serum of a survival-promoting factor for cultured central neurons and its identification as selenoprotein-P. Yan, J., Barrett, J.N. J. Neurosci. (1998) [Pubmed]
  25. Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. Gerasimovskaya, E.V., Ahmad, S., White, C.W., Jones, P.L., Carpenter, T.C., Stenmark, K.R. J. Biol. Chem. (2002) [Pubmed]
  26. Purification of a new high activity form of glucose-6-phosphate dehydrogenase from rat liver and the effect of enzyme inactivation on its immunochemical reactivity. Dao, M.L., Watson, J.J., Delaney, R., Johnson, B.C. J. Biol. Chem. (1979) [Pubmed]
  27. The three recombinant domains of human serum albumin. Structural characterization and ligand binding properties. Dockal, M., Carter, D.C., Rüker, F. J. Biol. Chem. (1999) [Pubmed]
  28. Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin. Rao, P.V., Horwitz, J., Zigler, J.S. J. Biol. Chem. (1994) [Pubmed]
  29. The thioredoxin system of Helicobacter pylori. Windle, H.J., Fox, A., Ní Eidhin, D., Kelleher, D. J. Biol. Chem. (2000) [Pubmed]
  30. Human alpha fetoprotein enhances epidermal growth factor proliferative activity upon porcine granulosa cells in monolayer culture. Leal, J.A., May, J.V., Keel, B.A. Endocrinology (1990) [Pubmed]
  31. Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase. Thomson, A.M., Meyer, D.J., Hayes, J.D. Biochem. J. (1998) [Pubmed]
  32. Assembly of phosphofructokinase-1 from Saccharomyces cerevisiae in extracts of single-deletion mutants. Klinder, A., Kirchberger, J., Edelmann, A., Kopperschläger, G. Yeast (1998) [Pubmed]
  33. A microassay for the determination of binding parameters of estrogen and androgen receptors employing affinity immobilization on Cibacron blue 3GA-Sepharose 6B. Iqbal, M.J., Corbishley, T.P., Wilkinson, M.L., Williams, R. Anal. Biochem. (1985) [Pubmed]
  34. Binding of Cibacron blue F3GA to proteins containing the dinucleotide fold. Thompson, S.T., Stellwagen, E. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  35. An allosteric synthetic DNA. Wu, L., Curran, J.F. Nucleic Acids Res. (1999) [Pubmed]
  36. Characterization and partial purification of a serum protein which stimulates the release of human placental lactogen in vitro. Barrett, J., Golander, A., Conn, P.M., Handwerger, S. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  37. Monocyte chemotactic activity induced by intravitreal endotoxin. Rosenbaum, J.T., Raymond, W. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  38. Rapid, single-step purification of restriction endonucleases on cibacron blue F3GA-agarose. Baksi, K., Rogerson, D.L., Rushizky, G.W. Biochemistry (1978) [Pubmed]
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