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Gene Review

SOX17  -  SRY (sex determining region Y)-box 17

Homo sapiens

Synonyms: Transcription factor SOX-17
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High impact information on SOX17


Biological context of SOX17


Anatomical context of SOX17

  • HESCs are capable of spontaneous differentiation to cells expressing the definitive endoderm and pancreatic progenitor markers Foxa2, Sox17, and Pdx1, and ultimately, some cells express islet endocrine hormones [4].

Analytical, diagnostic and therapeutic context of SOX17


  1. Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Poulain, M., Fürthauer, M., Thisse, B., Thisse, C., Lepage, T. Development (2006) [Pubmed]
  2. Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. Suraweera, N., Robinson, J., Volikos, E., Guenther, T., Talbot, I., Tomlinson, I., Silver, A. Int. J. Cancer (2006) [Pubmed]
  3. Molecular cloning and characterization of human SOX17. Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  4. Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells. Xu, X., Kahan, B., Forgianni, A., Jing, P., Jacobson, L., Browning, V., Treff, N., Odorico, J. Cloning Stem Cells (2006) [Pubmed]
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