Disease relevance of Pnpo

• The present study provided evidence that Pnpo is a candidate gene responsible for hypertension in Dahl-S rats [1].

High impact information on Pnpo

• As HTC cells did not have any demonstrable pyridoxine-5'-phosphate oxidase activity, the conversion of pyridoxine to pyridoxal 5'-phosphate must have taken place by a nonconventional route [2].
• Regardless of the prior nutritional status of their dams, at 14 days of age pups nursed by restricted dams (R-L, R-BPL) were smaller and had less carcass fat and lower plasma albumin, plasma and liver vitamin A, and liver pyridoxine 5'-phosphate oxidase values than those nursed by dams fed ad libitum (C, R-B, R-BP) [3].
• The correlation analysis between genotypes of differentially expressed genes and BP in F2 rats indicated that pyridoxine 5'-phosphate oxidase (Pnpo) and catecholamine-O-methyltransferease (Comt) showed a highly significant association with BP [1].
• The specific activity level of pyridoxal kinase decreased 3.2 times and that of pyridoxine 5'-phosphate oxidase increased 1.5 times in the state of deficiency [4].

References