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Gene Review

Pdxk  -  pyridoxal (pyridoxine, vitamin B6) kinase

Rattus norvegicus

Synonyms: Pkh, Pyridoxal kinase, Pyridoxine kinase
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Disease relevance of Pdxk

  • The pyridoxal phosphate content and the activities of pyridoxine kinase and pyridoxine phosphate oxidase of all Morris hepatomas examined were significantly less than those in adult host or control livers and generally fell in the range determined for fetal and neonatal liver [1].
  • Consistently significant differences in enzyme activities between the two groups of animals were found only in pyridoxine kinase indicating that this enzyme plays a key role during the development of vitamin B-6 deficiency [2].
  • The activities of pyridoxal kinase in the basal ganglion (3.84 +/- 0.23 vs. 4.99 +/- 0.11 microgram pyridoxal phosphate/mg protein/15 min) and in the cerebral cortex (3.40 +/- 0.06 vs. 3.70 +/- 0.04 microgram pyridoxal phosphate/mg protein/15 min) were lower in seizure-prone rats than in seizure-resistant rats [3].

High impact information on Pdxk


Chemical compound and disease context of Pdxk


Biological context of Pdxk

  • In light of the suggestion that phosphorylation and binding to proteins serve to prevent the diffusion of B-6 vitamers out of cells, the differential response of pyridoxine kinase activity in liver and brain may be important in the maintenance of the vitamin B-6 supply in the central nervous system [2].

Anatomical context of Pdxk


Associations of Pdxk with chemical compounds


Other interactions of Pdxk


Analytical, diagnostic and therapeutic context of Pdxk


  1. Vitamin B6 metabolism in liver and liver-derived tumors. Meisler, N.T., Nutter, L.M., Thanassi, J.W. Cancer Res. (1982) [Pubmed]
  2. Pyridoxine kinase, pyridoxine phosphate phosphatase and pyridoxine phosphate oxidase activities in control and B-6-deficient rat liver and brain. Meisler, N.T., Thanassi, J.W. J. Nutr. (1980) [Pubmed]
  3. The status of vitamin B6 metabolism in brains of genetically epilepsy-prone rats. Ebadi, M., Jobe, P.C., Laird, H.E. Epilepsia (1985) [Pubmed]
  4. Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor. Hanna, M.C., Turner, A.J., Kirkness, E.F. J. Biol. Chem. (1997) [Pubmed]
  5. Metabolism of vitamin B6 in rat liver mitochondria. Lui, A., Lumeng, L., Li, T.K. J. Biol. Chem. (1981) [Pubmed]
  6. Effects of epsilon-pyridoxyllysine and related compounds on liver and brain pyridoxal kinase and liver pyridoxamine (pyridoxine) 5'-phosphate oxidase. Gregory, J.F. J. Biol. Chem. (1980) [Pubmed]
  7. Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro. Takeuchi, F., Tsubouchi, R., Shibata, Y. Biochem. J. (1985) [Pubmed]
  8. Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat. Coburn, S.P., Mahuren, J.D., Schaltenbrand, W.E., Wostmann, B.S., Madsen, D. J. Nutr. (1981) [Pubmed]
  9. On the inhibitory activity of 4-vinyl analogues of pyridoxal: enzyme and cell culture studies. Korytnyk, W., Hakala, M.T., Potti, P.G., Angelino, N., Chang, S.C. Biochemistry (1976) [Pubmed]
  10. Tat-mediated protein transduction of human brain pyridoxal kinase into PC12 cells. Kim, D.W., Kim, C.K., Choi, S.H., Choi, H.S., Kim, S.Y., An, J.J., Lee, S.R., Lee, S.H., Kwon, O.S., Kang, T.C., Won, M.H., Cho, Y.J., Cho, S.W., Kang, J.H., Kim, T.Y., Lee, K.S., Park, J., Eum, W.S., Choi, S.Y. Biochimie (2005) [Pubmed]
  11. Levodopa-mediated alteration in the activity of pyridoxal kinase in rat basal ganglia. Ebadi, M., Bifano, J., Klangkalya, B., Govitrapong, P., Durham, P. Pharmacology (1978) [Pubmed]
  12. Effect of contraceptive steroids on gamma-aminobutyric acid metabolism and pyridoxal kinase activity in rat brain. Shetty, K.T., Gaitonde, B.B. Exp. Neurol. (1980) [Pubmed]
  13. Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores. Van den Berg, H., Bogaards, J.J. J. Nutr. (1987) [Pubmed]
  14. A fluorometric assay for pyridoxal kinase applicable to crude cell extracts. Sussmane, S., Koontz, J. Anal. Biochem. (1995) [Pubmed]
  15. Metabolism of pyridoxine in the liver of vitamin B-6-deficient rats. Tryfiates, G.P., Saus, F.L. Biochim. Biophys. Acta (1976) [Pubmed]
  16. The role of zinc and zinc-binding proteins in regulation of glutamic acid decarboxylase in brain. Ebadi, M., Wilt, S., Ramaley, R., Swanson, S., Mebus, C. Prog. Clin. Biol. Res. (1984) [Pubmed]
  17. Rapid purification by affinity chromatography of rat brain pyridoxal kinase and pyridoxamine-5-phosphate oxidase. Cash, C.D., Maitre, M., Rumigny, J.F., Mandel, P. Biochem. Biophys. Res. Commun. (1980) [Pubmed]
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