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Gene Review

Nolc1  -  nucleolar and coiled-body phosphoprotein 1

Rattus norvegicus

Synonyms: 140 kDa nucleolar phosphoprotein, Nopp140, Nucleolar 130 kDa protein, Nucleolar and coiled-body phosphoprotein 1, Nucleolar phosphoprotein p130
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Disease relevance of Nolc1


High impact information on Nolc1

  • Nopp140 is a nucleolar phosphoprotein of 140 kd that we originally identified and purified as a nuclear localization signal (NLS)-binding protein [2].
  • Indeed, Nopp140 is one of the most phosphorylated proteins in the cell, and NLS binding was dependent on phosphorylation [2].
  • Immunofluorescence and immunogold electron microscopy with NAP57 specific antibodies show colocalization with Nopp140 to the dense fibrillar component of the nucleolus, to coiled bodies, and to the nucleoplasm [3].
  • Immunogold staining in the nucleoplasm is occasionally seen in the form of curvilinear tracks between the nucleolus and the nuclear envelope, similar to those previously reported for Nopp140 [3].
  • Using coimmunoprecipitation experiments, we show that the nucleolar and coiled-body protein Nopp140 interacts with both classes of snoRNPs [4].

Biological context of Nolc1

  • Based on its subcellular location, its nuclear localization signal binding capacity, and its shuttling between the nucleolus and the cytoplasm, Nopp140 was proposed to function as a chaperone in ribosome biogenesis [5].
  • Nopp140 is a nuclear localisation signal binding protein that shuttles on curvilinear tracks between the nucleolus and the cytoplasm [6].
  • Because Nopp140 is involved in the regulation of transcriptional activity it could play a role in the osmosignalling pathway towards gene expression in H4IIE cells and hepatocytes [1].

Anatomical context of Nolc1


Analytical, diagnostic and therapeutic context of Nolc1


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