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Pik3c3  -  phosphatidylinositol 3-kinase, catalytic...

Rattus norvegicus

Synonyms: PI3-kinase type 3, PI3K type 3, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphoinositide-3-kinase class 3, PtdIns-3-kinase type 3, ...
 
 
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High impact information on Pik3c3

  • Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells [1].
  • Both wortmannin and injection of inhibitory Vps34p antibodies led to the accumulation of resident apical proteins in enlarged prelysosomes, whereas transcytosing apical proteins and recycling basolateral receptors transiently accumulated in basolateral early endosomes [1].
  • To understand how the Vps34p catalytic product, PI3P, was differentially regulating endocytosis from the two domains, we examined the PI3P binding protein early endosomal antigen 1 (EEA1) [1].
  • To investigate the possible role(s) of mammalian Vps34p in protein targeting to lysosomes, we have cloned the rat orthologue and overexpressed a kinase-deficient mutant in HeLa cells [2].
  • Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation [2].
 

Anatomical context of Pik3c3

  • We further suggest that inhibition of a wortmannin-sensitive enzyme, other than mammalian Vps34p, is responsible for the failure to recycle unoccupied mannose 6-phosphate receptors to the trans-Golgi network, and consequent hypersecretion of lysosomal enzyme precursors observed in the presence of this drug [2].
  • We propose that mammalian Vps34p plays a direct role in targeting lysosomal enzyme precursors to the endocytic pathway in an analogous fashion to its role in the fusion of early endocytic vesicles with endosomes [2].
  • The best example of this is provided by the class III phosphoinositide 3-kinase (PI-3K), Vps34p, which is required for correct targeting of newly synthesized carboxypeptidase Y to the yeast vacuole [2].

References

  1. Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. Tuma, P.L., Nyasae, L.K., Backer, J.M., Hubbard, A.L. J. Cell Biol. (2001) [Pubmed]
  2. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Row, P.E., Reaves, B.J., Domin, J., Luzio, J.P., Davidson, H.W. Biochem. J. (2001) [Pubmed]
 
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