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Gene Review

Asb4  -  ankyrin repeat and SOCS box-containing 4

Mus musculus

Synonyms: 8430401O13Rik, ASB-4, AV117194, AW060255, Ankyrin repeat and SOCS box protein 4
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High impact information on Asb4

  • One complementary deoxyribonucleic acid clone of a low-molecular-weight mRNA (asb4/134) is specific to the distal small bowel, specifically accumulates at weaning, and hybridizes to RNA from mouse testis and brain at approximately 2%-5% of the intestinal level [1].
  • Recently, two imprinted genes, paternally expressed Sgce and maternally expressed Asb4, were identified in this region [2].
  • Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that Asb-4 is a gene involved in energy homeostasis [3].
  • Reverse transcription quantitative polymerase chain reaction was used to validate down-regulation of Asb-4 mRNA in the arcuate nucleus of the fasted Sprague-Dawley rat (relative expression of Asb-4 mRNA: fed = 4.66 +/- 0.26; fasted = 3.96 +/- 0.23; n = 4, P < 0.01) [3].
  • Down-regulation was also demonstrated in the obese fa/fa Zucker rat, another model of energy disequilibrium (relative expression of Asb-4 mRNA: lean Zucker = 3.91 +/- 0.32; fa/fa = 2.93 +/- 0.26; n = 5, P < 0.001) [3].

Biological context of Asb4

  • One of the down-regulated mRNAs was ankyrin-repeat and suppressor of cytokine signalling box-containing protein 4 (Asb-4) [3].

Anatomical context of Asb4


  1. Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine. Ouellette, A.J., Cordell, B. Gastroenterology (1988) [Pubmed]
  2. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Ono, R., Shiura, H., Aburatani, H., Kohda, T., Kaneko-Ishino, T., Ishino, F. Genome Res. (2003) [Pubmed]
  3. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. Li, J.Y., Kuick, R., Thompson, R.C., Misek, D.E., Lai, Y.M., Liu, Y.Q., Chai, B.X., Hanash, S.M., Gantz, I. J. Neuroendocrinol. (2005) [Pubmed]
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