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Gene Review

Sgce  -  sarcoglycan, epsilon

Mus musculus

Synonyms: Epsilon-SG, Epsilon-sarcoglycan, e-SG
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Disease relevance of Sgce


High impact information on Sgce

  • Overexpression of epsilon-SG in normal mice resulted in substitution of epsilon-SG for alpha-SG in the SG complex of skeletal muscle without any obvious abnormalities [2].
  • Several transgenic mouse lines that overexpress epsilon-SG in skeletal muscle were established [2].
  • Here we show that the epsilon-sarcoglycan gene (Sgce) and Zac1 (Lot1) are both paternally expressed imprinted genes [3].
  • 5. Sgce is located at the proximal end of mouse chromosome 6 and is a candidate gene for embryonic lethality associated with uniparental maternal inheritance of this region [3].
  • Recently, two imprinted genes, paternally expressed Sgce and maternally expressed Asb4, were identified in this region [4].

Biological context of Sgce


Anatomical context of Sgce


Other interactions of Sgce

  • Peg10, which is next to Sgce, shows complete paternal expression, like Sgce [4].
  • Thus, the goal of the present study was to investigate whether overexpression of epsilon-SG can compensate for dysfunction of alpha-SG [2].

Analytical, diagnostic and therapeutic context of Sgce


  1. Myoclonus, motor deficits, alterations in emotional responses and monoamine metabolism in epsilon-sarcoglycan deficient mice. Yokoi, F., Dang, M.T., Li, J., Li, Y. J. Biochem. (2006) [Pubmed]
  2. Epsilon-sarcoglycan compensates for lack of alpha-sarcoglycan in a mouse model of limb-girdle muscular dystrophy. Imamura, M., Mochizuki, Y., Engvall, E., Takeda, S. Hum. Mol. Genet. (2005) [Pubmed]
  3. Zac1 (Lot1), a potential tumor suppressor gene, and the gene for epsilon-sarcoglycan are maternally imprinted genes: identification by a subtractive screen of novel uniparental fibroblast lines. Piras, G., El Kharroubi, A., Kozlov, S., Escalante-Alcalde, D., Hernandez, L., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Stewart, C.L. Mol. Cell. Biol. (2000) [Pubmed]
  4. Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6. Ono, R., Shiura, H., Aburatani, H., Kohda, T., Kaneko-Ishino, T., Ishino, F. Genome Res. (2003) [Pubmed]
  5. Cloning, developmental regulation and neural localization of rat epsilon-sarcoglycan. Xiao, J., LeDoux, M.S. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  6. Identification and characterization of epsilon-sarcoglycans in the central nervous system. Nishiyama, A., Endo, T., Takeda, S., Imamura, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
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