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Gene Review

SNRPD3  -  small nuclear ribonucleoprotein D3...

Homo sapiens

Synonyms: SMD3, Sm-D3, Small nuclear ribonucleoprotein Sm D3, snRNP core protein D3
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Disease relevance of SNRPD3


High impact information on SNRPD3


Biological context of SNRPD3


Other interactions of SNRPD3

  • JBP1 binds SmD1 and SmD3 via their RG domains, while pICln binds the Sm domains [5].


  1. PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. Lee, J.H., Cook, J.R., Yang, Z.H., Mirochnitchenko, O., Gunderson, S.I., Felix, A.M., Herth, N., Hoffmann, R., Pestka, S. J. Biol. Chem. (2005) [Pubmed]
  2. Improved serological differentiation between systemic lupus erythematosus and mixed connective tissue disease by use of an SmD3 peptide-based immunoassay. Mahler, M., Stinton, L.M., Fritzler, M.J. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
  3. SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Friesen, W.J., Massenet, S., Paushkin, S., Wyce, A., Dreyfuss, G. Mol. Cell (2001) [Pubmed]
  4. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. Charroux, B., Pellizzoni, L., Perkinson, R.A., Shevchenko, A., Mann, M., Dreyfuss, G. J. Cell Biol. (1999) [Pubmed]
  5. The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Friesen, W.J., Paushkin, S., Wyce, A., Massenet, S., Pesiridis, G.S., Van Duyne, G., Rappsilber, J., Mann, M., Dreyfuss, G. Mol. Cell. Biol. (2001) [Pubmed]
  6. The symmetrical dimethylarginine post-translational modification of the SmD3 protein is not required for snRNP assembly and nuclear transport. Khusial, P.R., Vaidya, K., Zieve, G.W. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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