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Gene Review

DDX20  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

Homo sapiens

Synonyms: Component of gems 3, DEAD box protein 20, DEAD box protein DP 103, DP103, GEMIN3, ...
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Disease relevance of DDX20


High impact information on DDX20

  • Gemin4 is associated in vivo with the SMN complex through a direct interaction with Gemin3 [2].
  • In both compartments SMN is part of a large complex that contains several proteins including Gemin2 (formerly SIP1) and the DEAD box protein Gemin3 [2].
  • Previous work has shown that DP103 binds viral proteins known to interact with a cellular transcription factor to modulate gene expression [3].
  • DP103 is expressed predominantly in the testis and is also expressed at a lower level in other steroidogenic and nonsteroidogenic tissues [4].
  • In addition, impaired transactivation of a DP103 binding-deficient EBNA2 mutant was rescued by overexpression of SMN [5].

Biological context of DDX20


Anatomical context of DDX20

  • Here we describe that in a human neuronal cell line, the miRNP proteins eIF2C2 (a member of the Argonaute family of proteins), Gemin3, and Gemin4 along with miRNAs cosediment with polyribosomes [7].
  • Quantitative analysis of endogenous protein colocalization in growth cones after three-dimensional reconstructions revealed a statistically nonrandom association of SMN with Gemin2 (40%) and Gemin3 (48%) [8].
  • Furthermore, a DP103 binding-deficient SMN mutant was released from nuclear gems and/or coiled bodies and further enhanced coactivation [5].
  • Here, we show that FOXL2 induces apoptosis in both Chinese hamster ovary cells and rat granulosa cells, and it interacts with DP103, a DEAD box-containing protein [6].
  • The repression is observed in five cell lines tested, while the degree of the repression varies greatly, which does not parallel with the expression level of the DEAD box protein of 130 kD (DP103), a potential interacting protein of a homologous domain in the steroidogenic factor 1 (SF-1) [9].


  1. Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems. Charroux, B., Pellizzoni, L., Perkinson, R.A., Shevchenko, A., Mann, M., Dreyfuss, G. J. Cell Biol. (1999) [Pubmed]
  2. Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. Charroux, B., Pellizzoni, L., Perkinson, R.A., Yong, J., Shevchenko, A., Mann, M., Dreyfuss, G. J. Cell Biol. (2000) [Pubmed]
  3. Direct interaction of Smn with dp103, a putative RNA helicase: a role for Smn in transcription regulation? Campbell, L., Hunter, K.M., Mohaghegh, P., Tinsley, J.M., Brasch, M.A., Davies, K.E. Hum. Mol. Genet. (2000) [Pubmed]
  4. The DEAD box protein DP103 is a regulator of steroidogenic factor-1. Ou, Q., Mouillet, J.F., Yan, X., Dorn, C., Crawford, P.A., Sadovsky, Y. Mol. Endocrinol. (2001) [Pubmed]
  5. Functional cooperation of Epstein-Barr virus nuclear antigen 2 and the survival motor neuron protein in transactivation of the viral LMP1 promoter. Voss, M.D., Hille, A., Barth, S., Spurk, A., Hennrich, F., Holzer, D., Mueller-Lantzsch, N., Kremmer, E., Grässer, F.A. J. Virol. (2001) [Pubmed]
  6. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Lee, K., Pisarska, M.D., Ko, J.J., Kang, Y., Yoon, S., Ryou, S.M., Cha, K.Y., Bae, J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. miRNP:mRNA association in polyribosomes in a human neuronal cell line. Nelson, P.T., Hatzigeorgiou, A.G., Mourelatos, Z. RNA (2004) [Pubmed]
  8. Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons. Zhang, H., Xing, L., Rossoll, W., Wichterle, H., Singer, R.H., Bassell, G.J. J. Neurosci. (2006) [Pubmed]
  9. Characterization of a strong repression domain in the hinge region of orphan nuclear receptor hB1F/hLRH-1. Xu, P.L., Shan, S.F., Kong, Y.Y., Xie, Y.H., Wang, Y. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2003) [Pubmed]
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