High impact information on Gatm

• The genes from the KCNQ1 domain and the isolated human orthologues of the imprinted genes Gatm and Dcn all are expressed biallelically in the human, from first-trimester trophoblast through to term [1].
• Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta [2].
• We show that a CpG island associated with Gatm is unmethylated, as is a large CpG island associated with a neighboring gene [2].
• In mouse, Gatm is expressed during development and is imprinted in the placenta and yolk sac, but not in embryonic tissues [2].
• The Gatm gene maps to mouse chromosome 2 in a region not previously shown to contain imprinted genes [2].

Associations of Gatm with chemical compounds

• In the kidney, L-Arg is converted to L-ornithine and guanidinoacetate (GAA) by L-arginine-glycine amidinotransferase [3].
• Hydrocortisone administration into male lizards did not significantly alter the transamidinase levels in kidney and liver [4].
• The present study investigates enzyme activities of the urea cycle, transamidinase and ornithine-proline inter-conversion in the hypertrophied kidney after unilateral nephrectomy in mice [5].

Other interactions of Gatm

• Kidney and liver in the lizard and kidney and pancreas in the mouse were the tissues with high transamidinase activity [4].

References