Gene Review:
GATM - glycine amidinotransferase (L...
Homo sapiens
Synonyms:
AGAT, AT, CCDS3, Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, ...
Debiton,
Glasser,
Marchenay,
Rolhion,
Maurizis,
Madelmont,
Brandes,
Tosoni,
Cavallo,
Bertorelle,
Gioia,
Franceschi,
Biscuola,
Blatt,
Crin??,
Ermani,
Brosnan,
Brosnan,
Brandes,
Basso,
Reni,
Vastola,
Tosoni,
Cavallo,
Scopece,
Ferreri,
Panucci,
Monfardini,
Ermani,
Wyss,
Schulze,
Carducci,
Birarelli,
Leuzzi,
Carducci,
Battini,
Cioni,
Antonozzi,
Tolcher,
Gerson,
Denis,
Geyer,
Hammond,
Patnaik,
Goetz,
Schwartz,
Edwards,
Reyderman,
Statkevich,
Cutler,
Rowinsky,
- Carmustine and streptozocin in refractory melanoma: an attempt at modulation of O-alkylguanine-DNA-alkyltransferase. Smith, D.C., Gerson, S.L., Liu, L., Donnelly, S., Day, R., Trump, D.L., Kirkwood, J.M. Clin. Cancer Res. (1996)
- Smoking-related increase in O6-alkylguanine-DNA alkyltransferase activity in human lung tissue. Drin, I., Schoket, B., Kostic, S., Vincze, I. Carcinogenesis (1994)
- Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules. Tolcher, A.W., Gerson, S.L., Denis, L., Geyer, C., Hammond, L.A., Patnaik, A., Goetz, A.D., Schwartz, G., Edwards, T., Reyderman, L., Statkevich, P., Cutler, D.L., Rowinsky, E.K. Br. J. Cancer (2003)
- Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? Wyss, M., Schulze, A. Neuroscience (2002)
- Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. Item, C.B., Stöckler-Ipsiroglu, S., Stromberger, C., Mühl, A., Alessandrì, M.G., Bianchi, M.C., Tosetti, M., Fornai, F., Cioni, G. Am. J. Hum. Genet. (2001)
- Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. Friedman, H.S., Dolan, M.E., Moschel, R.C., Pegg, A.E., Felker, G.M., Rich, J., Bigner, D.D., Schold, S.C. J. Natl. Cancer Inst. (1992)
- Gyrate atrophy of the choroid and retina with hyperornithinemia. Deficient formation of guanidinoacetic acid from arginine. Sipilä, I., Simell, O., Arjomaa, P. J. Clin. Invest. (1980)
- The differential contribution of arginase and transamidinase to ornithine biosynthesis in two achromic human melanoma cell lines. Thomasset, N., Quash, G.A., Doré, J.F. FEBS Lett. (1982)
- Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. Kurpad, S.N., Dolan, M.E., McLendon, R.E., Archer, G.E., Moschel, R.C., Pegg, A.E., Bigner, D.D., Friedman, H.S. Cancer Chemother. Pharmacol. (1997)
- Inhibition of O6-alkylguanine-DNA alkyltransferase by O6-benzyl-N2-acetylguanosine increases chloroethylnitrosourea-induced apoptosis in Mer+ human melanoma cells. Debiton, E., Glasser, A.L., Marchenay, C., Rolhion, C., Maurizis, J.C., Madelmont, J.C. Melanoma Res. (2002)
- Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue. Humm, A., Fritsche, E., Mann, K., Göhl, M., Huber, R. Biochem. J. (1997)
- The amino acid sequences of human and pig L-arginine:glycine amidinotransferase. Humm, A., Huber, R., Mann, K. FEBS Lett. (1994)
- A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. Hammond, L.A., Eckardt, J.R., Kuhn, J.G., Gerson, S.L., Johnson, T., Smith, L., Drengler, R.L., Campbell, E., Weiss, G.R., Von Hoff, D.D., Rowinsky, E.K. Clin. Cancer Res. (2004)
- Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO). Brandes, A.A., Tosoni, A., Cavallo, G., Bertorelle, R., Gioia, V., Franceschi, E., Biscuola, M., Blatt, V., Crin??, L., Ermani, M. Br. J. Cancer (2006)
- Evidence for creatine biosynthesis in Müller glia. Nakashima, T., Tomi, M., Tachikawa, M., Watanabe, M., Terasaki, T., Hosoya, K. Glia (2005)
- Renal arginine metabolism. Brosnan, M.E., Brosnan, J.T. J. Nutr. (2004)
- Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism. Stromberger, C., Bodamer, O.A., Stöckler-Ipsiroglu, S. J. Inherit. Metab. Dis. (2003)
- Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. Humm, A., Fritsche, E., Steinbacher, S., Huber, R. EMBO J. (1997)
- The ligand-induced structural changes of human L-Arginine:Glycine amidinotransferase. A mutational and crystallographic study. Fritsche, E., Humm, A., Huber, R. J. Biol. Chem. (1999)
- First-line chemotherapy with cisplatin plus fractionated temozolomide in recurrent glioblastoma multiforme: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia. Brandes, A.A., Basso, U., Reni, M., Vastola, F., Tosoni, A., Cavallo, G., Scopece, L., Ferreri, A.J., Panucci, M.G., Monfardini, S., Ermani, M. J. Clin. Oncol. (2004)
- The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase. McGuire, D.M., Tormanen, C.D., Segal, I.S., Van Pilsum, J.F. J. Biol. Chem. (1980)
- Estrogen modulates the expression of L-arginine:glycine amidinotransferase in chick liver. Zhu, Y., Evans, M.I. Mol. Cell. Biochem. (2001)
- Partial purification and properties of a transamidinase from Lathyrus sativus seedlings. Involvement in homoarginine metabolism and amine interconversions. Srivenugopal, K.S., Adiga, P.R. Biochem. J. (1980)
- Guanidinoacetate and creatine plus creatinine assessment in physiologic fluids: an effective diagnostic tool for the biochemical diagnosis of arginine:glycine amidinotransferase and guanidinoacetate methyltransferase deficiencies. Carducci, C., Birarelli, M., Leuzzi, V., Carducci, C., Battini, R., Cioni, G., Antonozzi, I. Clin. Chem. (2002)
- Substrate binding and catalysis by L-arginine:glycine amidinotransferase--a mutagenesis and crystallographic study. Fritsche, E., Humm, A., Huber, R. Eur. J. Biochem. (1997)
- The purification and characterization of human kidney L-arginine:glycine amidinotransferase. Gross, M.D., Eggen, M.A., Simon, A.M., Van Pilsum, J.F. Arch. Biochem. Biophys. (1986)