Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SNORA54 - small nucleolar RNA, H/ACA box 54

Homo sapiens

Synonyms: ACA54

Lavagna, C. et al., Hendrick, J.C. et al., Gérard, J.P. et al., Cohen, D. et al., Kermani-Arab, V. et al.

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Disease relevance of SNORA54

The main protein of the core of murine mammary tumor virus, with a molecular weight of 28,000 (p28), was solubilized by deoxycholate treatment of the virus and purified by Ultrogel ACA-54 filtration and hydroxyapatite chromatography [1].

High impact information on SNORA54

Gel filtration on Ultragel ACA 54 in 5 M guanidine 1 M acetic acid yielded components with molecular weights between 17,000 and 13,000 [2].
IL2 when tested in a [3H]thymidine incorporation assay by human IL2-dependent T cells, appeared to have a MW of 25,000 as determined by Ultrogel ACA 54 gel filtration [3].
The procedures applied include ammonium sulfate precipitation, ACA-54 gel filtration, ultrafiltration and chromatofocusing [4].

Associations of SNORA54 with chemical compounds

(2) After chromatography on hydroxylapatite, on DEAE and then on ACA 54 (gel permeation), a low-molecular-weight protein (15 kDa) called purified intestinal inhibitor (PII) was isolated (purification factor of approx. 50,000 with respect to the supernatant fraction) [5].

References

Radioimmunoassay for protein p28 of murine mammary tumor virus in organs and serum of mice and search for related antigens in human sera and breast cancer extracts. Hendrick, J.C., François, C., Calberg-Bacq, C.M., Colin, C., Franchimont, P., Gosselin, L., Kozma, S., Osterrieth, P.M. Cancer Res. (1978) [Pubmed]
Characterization of amyloid deposits and P component from a patient with factor X deficiency reveals proteins derived from a lambda VI light chain. Cohen, D., Pras, M., Franklin, E.C., Frangione, B. Am. J. Med. (1983) [Pubmed]
Chromatofocusing as a tool for the characterization and partial purification of human interleukin-2. Gérard, J.P., Bertoglio, J. J. Immunol. Methods (1982) [Pubmed]
Purification of human interleukin 2 produced from normal human peripheral blood mononuclear cells. Kermani-Arab, V., Uittenbogaart, C., Bramhall, J. Thymus (1986) [Pubmed]
Purification and biological properties of an epithelial intestinal cell growth inhibitor from a human small intestine. Lavagna, C., Douzinas, E., Nano, J.L., Rampal, P. Biochim. Biophys. Acta (1990) [Pubmed]

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