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Gene Review

SURF6  -  surfeit 6

Homo sapiens

Synonyms: FLJ30322, RRP14, SURF-6, Surfeit locus protein 6
 
 
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High impact information on SURF6

  • Approximately 40 kb proximal to the 3' end of the Surf-6 gene, the 5' region of the ABO glycosyltransferase gene has been detected [1].
  • We identified that the Saccharomyces cerevisiae member of the SURF-6 family, named rrp14 or ykl082c, has been categorized in yeast databases to interact with proteins involved in ribosomal biogenesis and cell polarity [2].
  • Deletion sequence analysis shows that multiple regions of the SURF-6 protein are capable of nucleolar targeting independently of the evolutionary conserved domain [2].
  • We propose that SURF-6 may be involved in processing of rRNA, based on its cytological characteristics, but at stages in ribosomal biogenesis which are different from those for fibrillarin and B23 [3].
  • The presence and nuclear distribution of SURF-6 during the cell cycle was explored by immunofluorescence analysis [3].
 

Biological context of SURF6

  • SURF-6 was found to be largely coincident with both proteins in interphase and it was distributed in the same cellular locations, namely the perichromosomal layer, the cytoplasm and prenucleolar bodies, in mitosis [3].
 

Anatomical context of SURF6

References

  1. The human Surfeit locus. Duhig, T., Ruhrberg, C., Mor, O., Fried, M. Genomics (1998) [Pubmed]
  2. Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast. Polzikov, M., Zatsepina, O., Magoulas, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro. Magoulas, C., Zatsepina, O.V., Jordan, P.W., Jordan, E.G., Fried, M. Eur. J. Cell Biol. (1998) [Pubmed]
 
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