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Gene Review

Dctn1  -  dynactin 1

Mus musculus

Synonyms: 150 kDa dynein-associated polypeptide, AL022633, DAP-150, DP-150, Dynactin subunit 1, ...
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Disease relevance of Dctn1


High impact information on Dctn1


Biological context of Dctn1


Anatomical context of Dctn1


Associations of Dctn1 with chemical compounds

  • Similar effects were seen upon inhibition of dynactin by dynamitin, and after prolonged treatment of cells with the microtubule inhibitor nocodazole [17].
  • Triton X-100-permeabilized proplatelets containing dynein and its regulatory complex, dynactin, but not kinesin, elongate with the addition of adenosine triphosphate (ATP) at a rate of 0.65 microm/min [18].
  • These observations indicate that polyglutamine-dependent transcriptional dysregulation of dynactin 1 plays a crucial role in the reversible neuronal dysfunction in the early stage of SBMA [4].

Physical interactions of Dctn1

  • Thus, we conclude that CyP-A associates in vitro and in vivo with the dynein/dynactin motor protein complex and we suggest that CyP-A may perform a general function related to the binding of cargo for retrograde movement along microtubules [19].

Regulatory relationships of Dctn1


Other interactions of Dctn1

  • Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a candidate for the neuromuscular disease mutation mnd2 [1].
  • In addition, the microtubule-associated proteins CLASP2 (a CLIP associating protein) and dynactin-p50 are found on kinetochores and a subset of microtubule-organising centres [20].
  • These immunophilins link to cytoplasmic dynein indirectly through the association of the immunophilin peptidylprolyl isomerase (PPIase) domain with dynamitin, a component of the dynein-associated dynactin complex (Galigniana, M. D., Harrell, J. M., O'Hagen, H. M., Ljungman, M., and Pratt, W. B. (2004) J. Biol. Chem. 279, 22483-22489) [19].
  • To define the basis for this interaction, pericentrin was coexpressed with cytoplasmic dynein heavy (DHCs), intermediate (DICs), and light intermediate (LICs) chains, and the dynamitin and p150(Glued) subunits of dynactin [21].

Analytical, diagnostic and therapeutic context of Dctn1

  • No decrease in dynein/dynactin expression was observed, but immunohistochemistry suggests that dynein associates with aggregates of mutant Cu/Zn superoxide dismutase 1 [3].


  1. Mouse p150Glued (dynactin 1) cDNA sequence and evaluation as a candidate for the neuromuscular disease mutation mnd2. Jang, W., Weber, J.S., Tokito, M.K., Holzbaur, E.L., Meisler, M.H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  2. Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus. Suomalainen, M., Nakano, M.Y., Boucke, K., Keller, S., Greber, U.F. EMBO J. (2001) [Pubmed]
  3. Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons. Ligon, L.A., LaMonte, B.H., Wallace, K.E., Weber, N., Kalb, R.G., Holzbaur, E.L. Neuroreport (2005) [Pubmed]
  4. Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration. Katsuno, M., Adachi, H., Minamiyama, M., Waza, M., Tokui, K., Banno, H., Suzuki, K., Onoda, Y., Tanaka, F., Doyu, M., Sobue, G. J. Neurosci. (2006) [Pubmed]
  5. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Akhmanova, A., Mausset-Bonnefont, A.L., van Cappellen, W., Keijzer, N., Hoogenraad, C.C., Stepanova, T., Drabek, K., van der Wees, J., Mommaas, M., Onderwater, J., van der Meulen, H., Tanenbaum, M.E., Medema, R.H., Hoogerbrugge, J., Vreeburg, J., Uringa, E.J., Grootegoed, J.A., Grosveld, F., Galjart, N. Genes Dev. (2005) [Pubmed]
  6. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. LaMonte, B.H., Wallace, K.E., Holloway, B.A., Shelly, S.S., Ascaño, J., Tokito, M., Van Winkle, T., Howland, D.S., Holzbaur, E.L. Neuron (2002) [Pubmed]
  7. Sunday Driver links axonal transport to damage signaling. Cavalli, V., Kujala, P., Klumperman, J., Goldstein, L.S. J. Cell Biol. (2005) [Pubmed]
  8. A role for cytoplasmic dynein and LIS1 in directed cell movement. Dujardin, D.L., Barnhart, L.E., Stehman, S.A., Gomes, E.R., Gundersen, G.G., Vallee, R.B. J. Cell Biol. (2003) [Pubmed]
  9. Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis. Carson, C., Saleh, M., Fung, F.W., Nicholson, D.W., Roskams, A.J. J. Neurosci. (2005) [Pubmed]
  10. Multiple mouse chromosomal loci for dynein-based motility. Vaughan, K.T., Mikami, A., Paschal, B.M., Holzbaur, E.L., Hughes, S.M., Echeverri, C.J., Moore, K.J., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Vallee, R.B. Genomics (1996) [Pubmed]
  11. Integrated radiation hybrid map of human chromosome 2p13: possible involvement of dynactin in neuromuscular diseases. Korthaus, D., Wedemeyer, N., Lengeling, A., Ronsiek, M., Jockusch, H., Schmitt-John, T. Genomics (1997) [Pubmed]
  12. Recognition of mammalian centromeres by anti-dynein and anti-dynactin components. Vig, B.K. Mutagenesis (1998) [Pubmed]
  13. EB1 identifies sites of microtubule polymerisation during neurite development. Morrison, E.E., Moncur, P.M., Askham, J.M. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  14. The presence of the 50-kDa subunit of dynactin complex in the nerve growth cone. Abe, T.K., Tanaka, H., Iwanaga, T., Odani, S., Kuwano, R. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  15. Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170. Valetti, C., Wetzel, D.M., Schrader, M., Hasbani, M.J., Gill, S.R., Kreis, T.E., Schroer, T.A. Mol. Biol. Cell (1999) [Pubmed]
  16. Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization. Palazzo, A.F., Joseph, H.L., Chen, Y.J., Dujardin, D.L., Alberts, A.S., Pfister, K.K., Vallee, R.B., Gundersen, G.G. Curr. Biol. (2001) [Pubmed]
  17. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. Dammermann, A., Merdes, A. J. Cell Biol. (2002) [Pubmed]
  18. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Patel, S.R., Richardson, J.L., Schulze, H., Kahle, E., Galjart, N., Drabek, K., Shivdasani, R.A., Hartwig, J.H., Italiano, J.E. Blood (2005) [Pubmed]
  19. Cyclophilin-A is bound through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex. Galigniana, M.D., Morishima, Y., Gallay, P.A., Pratt, W.B. J. Biol. Chem. (2004) [Pubmed]
  20. PAR-1 and the microtubule-associated proteins CLASP2 and dynactin-p50 have specific localisation on mouse meiotic and first mitotic spindles. Moore, C.A., Zernicka-Goetz, M. Reproduction (2005) [Pubmed]
  21. Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization. Purohit, A., Tynan, S.H., Vallee, R., Doxsey, S.J. J. Cell Biol. (1999) [Pubmed]
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