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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ube2v2  -  ubiquitin-conjugating enzyme E2 variant 2

Mus musculus

Synonyms: 1110021H13Rik, 4632410D19Rik, 5730524P06Rik, 6820402M05, AI848315, ...
 
 
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High impact information on Ube2v2

  • Valsartan also enhanced MMS2 expression to a greater degree in wild-type mice [1].
  • Angiotensin II treatment of neurospheres enhanced their differentiation and increased MMS2 expression [1].
  • Knockdown of the MMS2 gene by small interference RNA (siRNA) significantly reduced the number of neurospheres, with loss of sphere formation [1].
  • Here, we investigated the effect of angiotensin II type-2 (AT2) receptor stimulation on neurons and cognitive function involving a new neuroprotective factor, methyl methanesulfonate sensitive 2 (MMS2) [1].
  • An angiotensin II type-1 receptor blocker, valsartan, enhanced such neurosphere differentiation and MMS2 induction, whereas an AT2 receptor antagonist, PD123319, inhibited them [1].
 

Biological context of Ube2v2

  • To further investigate cellular roles played by mammalian Mms2 homologs, we report here the molecular cloning, tissue distribution and functional characterization of two mouse cDNAs encoding mMMS2 and mCROC1 [2].
  • Yeast Mms2 is a Ubc variant and plays an important role in error-free DNA postreplication repair to protect cells from killing by DNA damaging agents and mutagenesis [2].
 

Anatomical context of Ube2v2

  • Finally, intracerebroventricular administration of MMS2 siRNA showed more impaired avoidance rate after middle cerebral artery occlusion compared with that in control siRNA-transfected mice [1].

References

  1. Angiotensin II type-2 receptor stimulation prevents neural damage by transcriptional activation of methyl methanesulfonate sensitive 2. Mogi, M., Li, J.M., Iwanami, J., Min, L.J., Tsukuda, K., Iwai, M., Horiuchi, M. Hypertension (2006) [Pubmed]
  2. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko, J., Ashley, C., Xiao, W. Biochim. Biophys. Acta (2001) [Pubmed]
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