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Gene Review

UBE2V2  -  ubiquitin-conjugating enzyme E2 variant 2

Homo sapiens

Synonyms: DDVIT1, DDVit 1, DDVit-1, EDAF-1, EDPF-1, ...
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Disease relevance of UBE2V2


High impact information on UBE2V2

  • The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae [3].
  • Aurora-A in a complex with UBE2N/MMS2 catalyses polyubiquitination of IkappaBalpha in vitro and in vivo [4].
  • Both RWLeu-4 and JMRD3 express similar vitamin D3 receptors and vitamin D3-inducible enzyme activities [5].
  • Ang II induced MMS2 expression in a dose-dependent manner, reaching a peak after 4 h of stimulation, and this effect was enhanced with AT(1) receptor blocker, valsartan, but inhibited by AT(2) receptor blocker PD123319 [6].
  • These results provide a new insight into the contribution of AT(2) receptor stimulation to neural differentiation via transactivation of MMS2 expression involving the association of ATIP and SHP-1 [6].

Chemical compound and disease context of UBE2V2

  • Comparisons of their sensitivities to the bifunctional alkylating agents cis-platinum (II) diammine dichloride, mitomycin C and melphalan reveals marked phenotypic diversity, with only one mutant, designated MMS-2, exhibiting appreciable hypersensitivity to all of these agents [7].

Biological context of UBE2V2

  • To ask whether a similar mechanism contributes to abasic site-induced immunoglobulin gene conversion, and to ascertain the role of UBE2V2 in the vertebrate DNA damage response we created a ube2v2 mutant of the chicken cell line DT40 [1].
  • The hMMS2 and CROC-1 genes are able to functionally complement the yeast mms2 defects with regard to sensitivity to DNA damaging agents and spontaneous mutagenesis [8].
  • Using the rapid amplification of cDNA Ends (RACE)-PCR we got a transcript (DDVit 1) of a length of 1251 bp containing an open reading frame that encodes a putative 16,5 kD protein [9].
  • Conversely, both MMS2 and hMMS2 were able to transactivate a c- fos - CAT reporter gene in Rat-1 cells in a transient co-transfection assay [8].
  • A mutation in genes of either the MMS2 or the REV3 branch does not result in extreme sensitivity to DNA-damaging agents; however, deletion of both subpathways of PRR results in a synergistic phenotype [10].

Anatomical context of UBE2V2


Associations of UBE2V2 with chemical compounds


Other interactions of UBE2V2

  • The microarray showed that the most strongly up-regulated gene by 5-FU was vitamin D3 up-regulated protein 1 (VDUP1), an interesting stress response gene, which was originally reported as a vitamin D3 inducible gene in HL-60 [13].


  1. UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40. Simpson, L.J., Sale, J.E. DNA Repair (Amst.) (2005) [Pubmed]
  2. Bedside multimarker testing for risk stratification in chest pain units: The chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. Newby, L.K., Storrow, A.B., Gibler, W.B., Garvey, J.L., Tucker, J.F., Kaplan, A.L., Schreiber, D.H., Tuttle, R.H., McNulty, S.E., Ohman, E.M. Circulation (2001) [Pubmed]
  3. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Hofmann, R.M., Pickart, C.M. Cell (1999) [Pubmed]
  4. The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of I{kappa}B{alpha}. Briassouli, P., Chan, F., Linardopoulos, S. Hum. Mol. Genet. (2006) [Pubmed]
  5. Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line. Lasky, S.R., Posner, M.R., Iwata, K., Santos-Moore, A., Yen, A., Samuel, V., Clark, J., Maizel, A.L. Blood (1994) [Pubmed]
  6. Angiotensin II-Induced Neural Differentiation via Angiotensin II Type 2 (AT2) Receptor-MMS2 Cascade Involving Interaction between AT2 Receptor-Interacting Protein and Src Homology 2 Domain-Containing Protein-Tyrosine Phosphatase 1. Li, J.M., Mogi, M., Tsukuda, K., Tomochika, H., Iwanami, J., Min, L.J., Nahmias, C., Iwai, M., Horiuchi, M. Mol. Endocrinol. (2007) [Pubmed]
  7. Isolation of alkylating agent-sensitive Chinese hamster ovary cell lines. Robson, C.N., Hickson, I.D. Carcinogenesis (1987) [Pubmed]
  8. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L., Wei, Y.F. Nucleic Acids Res. (1998) [Pubmed]
  9. Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Fritsche, J., Rehli, M., Krause, S.W., Andreesen, R., Kreutz, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. DNA damage checkpoints are involved in postreplication repair. Barbour, L., Ball, L.G., Zhang, K., Xiao, W. Genetics (2006) [Pubmed]
  11. C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. Sugiki, H., Hozumi, Y., Maeshima, H., Katagata, Y., Mitsuhashi, Y., Kondo, S. Br. J. Dermatol. (2000) [Pubmed]
  12. Differential effects on cell killing in metallothionein overexpressing CHO mutant cell lines. Lohrer, H., Robson, T., Grindley, H., Foster, S., Hall, A. Carcinogenesis (1990) [Pubmed]
  13. Up-regulation of vitamin D3 up-regulated protein 1 gene in response to 5-fluorouracil in colon carcinoma SW620. Takahashi, Y., Nagata, T., Ishii, Y., Ikarashi, M., Ishikawa, K., Asai, S. Oncol. Rep. (2002) [Pubmed]
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