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Gene Review

Ubc  -  ubiquitin C

Mus musculus

Synonyms: 2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, ...
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Disease relevance of Ubc


High impact information on Ubc

  • Remarkably, the asymmetric arrangement of the TPR domains in the CHIP dimer occludes one Ubc binding site, so that CHIP operates with half-of-sites activity, providing an elegant means for coupling a dimeric chaperone to a single ubiquitylation system [2].
  • Its protein product contains a domain, Ubc, characteristic of the catalytic domain of ubiquitin conjugase (E2) enzymes but lacking an active-site cysteine crucial for ubiquitin conjugase activity [3].
  • We isolated four genes that were highly expressed in B16-F10 cells but not in B16-BL6 cells: TI-225 (polyubiquitin), TI-229 (pyruvate kinase), TI-241 (LRF-1 homologue), and TI-227 (novel gene) [4].
  • Recent work has shown that peroxisome proliferator-activated receptor beta (PPARbeta) attenuates cell proliferation and skin carcinogenesis, and this is due in part to regulation of ubiquitin C expression [5].
  • To achieve higher levels of hCG, a double TG model was generated by cross-breeding the hCG beta-expressing mice with another TG line harboring a ubiquitin C/common alpha-subunit fusion gene [6].

Biological context of Ubc

  • Analysis of these sequences, as well as those of the previously reported Chinese hamster and rat poly-u genes, supports the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over events [7].
  • Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis [8].
  • To achieve efficient gene knockdown in mammals and to generate phenotypes of gene knockout, we designed a construct in which a Pol II (ubiquitin C) promoter drove the expression of an shRNA with a structure that mimics human miRNA miR-30a [9].

Associations of Ubc with chemical compounds

  • Uevs, although resembling Ubc in sequence and structure, lack the active site cysteine residue and are catalytically inactive [10].
  • CONCLUSIONS: Activation of the aromatase gene during an earlier developmental stage under the ubiquitin C promoter and highly elevated serum estrogen concentrations may explain the differences in voiding and prostate size in the AROM+ mouse strain [11].

Other interactions of Ubc


Analytical, diagnostic and therapeutic context of Ubc

  • Mouse and fly homologues of both ARI proteins and the Ubc can substitute for each other in the yeast two-hybrid assay, indicating that ARI represents a conserved novel mechanism in development [14].


  1. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Harbers, K., Müller, U., Grams, A., Li, E., Jaenisch, R., Franz, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Zhang, M., Windheim, M., Roe, S.M., Peggie, M., Cohen, P., Prodromou, C., Pearl, L.H. Mol. Cell (2005) [Pubmed]
  3. A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Li, L., Liao, J., Ruland, J., Mak, T.W., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials. Ishiguro, T., Nakajima, M., Naito, M., Muto, T., Tsuruo, T. Cancer Res. (1996) [Pubmed]
  5. Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. Kim, D.J., Murray, I.A., Burns, A.M., Gonzalez, F.J., Perdew, G.H., Peters, J.M. J. Biol. Chem. (2005) [Pubmed]
  6. Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. Rulli, S.B., Ahtiainen, P., Mäkelä, S., Toppari, J., Poutanen, M., Huhtaniemi, I. Endocrinology (2003) [Pubmed]
  7. Evolution of the mouse polyubiquitin-C gene. Perelygin, A.A., Kondrashov, F.A., Rogozin, I.B., Brinton, M.A. J. Mol. Evol. (2002) [Pubmed]
  8. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko, J., Ashley, C., Xiao, W. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. Xia, X.G., Zhou, H., Samper, E., Melov, S., Xu, Z. PLoS Genet. (2006) [Pubmed]
  10. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. Andersen, P.L., Zhou, H., Pastushok, L., Moraes, T., McKenna, S., Ziola, B., Ellison, M.J., Dixit, V.M., Xiao, W. J. Cell Biol. (2005) [Pubmed]
  11. Infravesical obstruction in aromatase over expressing transgenic male mice with increased ratio of serum estrogen-to-androgen concentration. Streng, T., Li, X., Lehtoranta, M., Mäkelä, S., Poutanen, M., Talo, A., Tekmal, R.R., Santti, R. J. Urol. (2002) [Pubmed]
  12. Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. Kim, D.J., Akiyama, T.E., Harman, F.S., Burns, A.M., Shan, W., Ward, J.M., Kennett, M.J., Gonzalez, F.J., Peters, J.M. J. Biol. Chem. (2004) [Pubmed]
  13. The protein profile of acetazolamide-treated sera in mice bearing Lewis neoplasm. Xiang, Y., Ma, B., Yu, H.M., Li, X.J. Life Sci. (2004) [Pubmed]
  14. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. Aguilera, M., Oliveros, M., Martínez-Padrón, M., Barbas, J.A., Ferrús, A. Genetics (2000) [Pubmed]
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