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Gene Review

Casp4  -  caspase 4, apoptosis-related cysteine...

Mus musculus

Synonyms: CASP-11, CASP-4, Casp11, Caspase-11, Caspase-4, ...
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Disease relevance of Casp4


High impact information on Casp4

  • Furthermore, we found that pro-caspase-11 physically interacts with pro-ICE in cells, and the expression of casp-11 is essential for activation of ICE [6].
  • Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 (and caspase-11 in mice), but the mechanism involved in the activation of the proinflammatory caspases remains elusive [7].
  • Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions [3].
  • Furthermore, the induction of caspase-11 was evident in the ischemic brains of wild-type mice, and OLGs exhibited resistance to brain ischemia in mice deficient in caspase-11, suggesting that caspase-11 is critically implicated in the mechanism(s) underlying ischemia-induced OLG death [8].
  • Using a positional scanning combinatorial library method, we found that the optimal cleavage site of caspase-11 was (I/L/V/P)EHD, similar to that of upstream caspases such as caspase-8 and -9 [9].

Chemical compound and disease context of Casp4


Biological context of Casp4


Anatomical context of Casp4


Associations of Casp4 with chemical compounds


Regulatory relationships of Casp4


Other interactions of Casp4

  • Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions [9].
  • Furthermore, we show that caspase-11-mediated apoptosis under septic condition is Bid-independent [1].
  • In addition, we provide biochemical evidence that other apoptosis initiator caspases (caspase-2 and -10) as well as a procaspase involved in inflammation (murine caspase-11) are also activated by oligomerization [23].
  • Cathepsin B-mediated activation of the proinflammatory caspase-11 [24].
  • Hypoxic induction of caspase-11 was observed in both mRNA and protein levels, and was mediated through p38 mitogen-activated protein kinase pathway [4].


  1. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Kang, S.J., Wang, S., Kuida, K., Yuan, J. Cell Death Differ. (2002) [Pubmed]
  2. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. Kang, S.J., Sanchez, I., Jing, N., Yuan, J. J. Neurosci. (2003) [Pubmed]
  3. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. Hisahara, S., Yuan, J., Momoi, T., Okano, H., Miura, M. J. Exp. Med. (2001) [Pubmed]
  4. Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microglia. Kim, N.G., Lee, H., Son, E., Kwon, O.Y., Park, J.Y., Park, J.H., Cho, G.J., Choi, W.S., Suk, K. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  5. Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Furuya, T., Hayakawa, H., Yamada, M., Yoshimi, K., Hisahara, S., Miura, M., Mizuno, Y., Mochizuki, H. J. Neurosci. (2004) [Pubmed]
  6. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998) [Pubmed]
  7. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Martinon, F., Burns, K., Tschopp, J. Mol. Cell (2002) [Pubmed]
  8. Caspases determine the vulnerability of oligodendrocytes in the ischemic brain. Shibata, M., Hisahara, S., Hara, H., Yamawaki, T., Fukuuchi, Y., Yuan, J., Okano, H., Miura, M. J. Clin. Invest. (2000) [Pubmed]
  9. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. Kang, S.J., Wang, S., Hara, H., Peterson, E.P., Namura, S., Amin-Hanjani, S., Huang, Z., Srinivasan, A., Tomaselli, K.J., Thornberry, N.A., Moskowitz, M.A., Yuan, J. J. Cell Biol. (2000) [Pubmed]
  10. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. Wang, S., Miura, M., Jung, Y., Zhu, H., Gagliardini, V., Shi, L., Greenberg, A.H., Yuan, J. J. Biol. Chem. (1996) [Pubmed]
  11. Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. Kang, S.J., Popat, R., Bragdon, C., Odonnell, K., Phelan, S., Yuan, J., Sonis, S.T. DNA Cell Biol. (2004) [Pubmed]
  12. Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1. Schauvliege, R., Vanrobaeys, J., Schotte, P., Beyaert, R. J. Biol. Chem. (2002) [Pubmed]
  13. Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway. Hur, J., Kim, S.Y., Kim, H., Cha, S., Lee, M.S., Suk, K. FEBS Lett. (2001) [Pubmed]
  14. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Morita, Y., Maravei, D.V., Bergeron, L., Wang, S., Perez, G.I., Tsutsumi, O., Taketani, Y., Asano, M., Horai, R., Korsmeyer, S.J., Iwakura, Y., Yuan, J., Tilly, J.L. Cell Death Differ. (2001) [Pubmed]
  15. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Kobori, M., Yang, Z., Gong, D., Heissmeyer, V., Zhu, H., Jung, Y.K., Gakidis, M.A., Rao, A., Sekine, T., Ikegami, F., Yuan, C., Yuan, J. Cell Death Differ. (2004) [Pubmed]
  16. The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide. Schotte, P., Schauvliege, R., Janssens, S., Beyaert, R. J. Biol. Chem. (2001) [Pubmed]
  17. Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1beta, and expression of caspase-11 in mice. Arai, H., Furuya, T., Yasuda, T., Miura, M., Mizuno, Y., Mochizuki, H. J. Biol. Chem. (2004) [Pubmed]
  18. C/EBP Homologous Protein (CHOP) Is Crucial for the Induction of Caspase-11 and the Pathogenesis of Lipopolysaccharide-Induced Inflammatio. Endo, M., Mori, M., Akira, S., Gotoh, T. J. Immunol. (2006) [Pubmed]
  19. Listeria monocytogenes infection in caspase-11-deficient mice. Mueller, N.J., Wilkinson, R.A., Fishman, J.A. Infect. Immun. (2002) [Pubmed]
  20. Flavonoid baicalein attenuates activation-induced cell death of brain microglia. Suk, K., Lee, H., Kang, S.S., Cho, G.J., Choi, W.S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  21. Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death. Hisahara, S., Takano, R., Shoji, S., Okano, H., Miura, M. J. Neural Transm. Suppl. (2000) [Pubmed]
  22. Dual role of inflammatory stimuli in activation-induced cell death of mouse microglial cells. Initiation of two separate apoptotic pathways via induction of interferon regulatory factor-1 and caspase-11. Lee, J., Hur, J., Lee, P., Kim, J.Y., Cho, N., Kim, S.Y., Kim, H., Lee, M.S., Suk, K. J. Biol. Chem. (2001) [Pubmed]
  23. Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases. Chang, D.W., Ditsworth, D., Liu, H., Srinivasula, S.M., Alnemri, E.S., Yang, X. J. Biol. Chem. (2003) [Pubmed]
  24. Cathepsin B-mediated activation of the proinflammatory caspase-11. Schotte, P., Van Criekinge, W., Van de Craen, M., Van Loo, G., Desmedt, M., Grooten, J., Cornelissen, M., De Ridder, L., Vandekerckhove, J., Fiers, W., Vandenabeele, P., Beyaert, R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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