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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Actr3  -  ARP3 actin-related protein 3

Mus musculus

Synonyms: 1200003A09Rik, Actin-like protein 3, Actin-related protein 3, Arp3
 
 
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Disease relevance of Actr3

  • RNA interference silencing of up to 90% of Arp3 protein expression, a major subunit of the Arp2/3 complex, proportionately decreases the intracellular motility of Listeria monocytogenes and actin nucleation activity ascribable to the Arp2/3 complex in mouse embryonic fibroblasts [1].
 

High impact information on Actr3

  • Furthermore, Arp3 accumulation at the phagosome was impaired after TAT-WD treatment [2].
  • While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3 [3].
 

Other interactions of Actr3

  • We find that Arp3, a component of the Arp2/3 complex, appears transiently while single clathrin-coated pits internalize [4].

References

  1. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Di Nardo, A., Cicchetti, G., Falet, H., Hartwig, J.H., Stossel, T.P., Kwiatkowski, D.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Coronin-1 function is required for phagosome formation. Yan, M., Collins, R.F., Grinstein, S., Trimble, W.S. Mol. Biol. Cell (2005) [Pubmed]
  3. Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant. Stevens, J.M., Ulrich, R.L., Taylor, L.A., Wood, M.W., Deshazer, D., Stevens, M.P., Galyov, E.E. J. Bacteriol. (2005) [Pubmed]
  4. Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts. Merrifield, C.J., Qualmann, B., Kessels, M.M., Almers, W. Eur. J. Cell Biol. (2004) [Pubmed]
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