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Gene Review:

Gtf2e1 - general transcription factor II E,...

Mus musculus

Synonyms: 2610024P03Rik, 56kDa, AI303800, FE, General transcription factor IIE 56 kDa subunit, ...

Ishii, Y. et al., Khabiri, A.R. et al., Surwit, R.S. et al., Wabakken, T. et al.

Khabiri, Bagheri, Alimohammadian, Assmar, Nadaf,

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Disease relevance of Gtf2e1

The increase in FE was related to adipocyte hyperplasia in B/6J mice on high-fat diets [1].
The purified antigen, which gave a single band of 56kDa on sodium dodecyl sulfate polyacrylamide gel electrophoresis elicited a strong delayed-type hypersensitivity (DTH) reaction in guinea pigs sensitized with L. major [2].

High impact information on Gtf2e1

This human protein, denoted solute carrier family 41 member 1 (SLC41A1), consists of 513 amino acids with an estimated molecular weight of 56kDa [3].
The amino acid sequence of peptide fragments from the protein digested in situ, was highly similar to a 56kDa selenium binding protein and similar to an acetaminophen binding protein in mice [4].
We obtained evidence that a toxic coplanar polychlorinated biphenyl (PCB) induces a counterpart of murine 56kDa selenium binding protein in rat liver cytosol [4].
In the absence of fat, sucrose produced a decreased in FE in both strains [1].

References

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Surwit, R.S., Feinglos, M.N., Rodin, J., Sutherland, A., Petro, A.E., Opara, E.C., Kuhn, C.M., Rebuffé-Scrive, M. Metab. Clin. Exp. (1995) [Pubmed]
Leishmanin skin test in guinea pig with a single purified protein of Leishmania major. Khabiri, A.R., Bagheri, F., Alimohammadian, M.H., Assmar, M., Nadaf, S.R. Exp. Parasitol. (2005) [Pubmed]
The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Wabakken, T., Rian, E., Kveine, M., Aasheim, H.C. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver. Ishii, Y., Hatsumura, M., Ishida, T., Ariyoshi, N., Oguri, K. Chemosphere (1996) [Pubmed]

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AgaP_AGAP006355	Anopheles gambiae str. PEST
GTF2E1	Bos taurus
CELE_ZK550.4	Caenorhabditis elegans
GTF2E1	Canis lupus familiaris
gtf2e1	Danio rerio
TfIIEalpha	Drosophila melanogaster
GTF2E1	Gallus gallus
GTF2E1	Homo sapiens
GTF2E1	Macaca mulatta
GTF2E1	Pan troglodytes
Gtf2e1	Rattus norvegicus
gtf2e1	Xenopus (Silurana) tropicalis

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