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Gene Review

GTF2E1  -  general transcription factor IIE,...

Homo sapiens

Synonyms: FE, General transcription factor IIE 56 kDa subunit, General transcription factor IIE subunit 1, TF2E1, TFIIE-A, ...
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Disease relevance of GTF2E1


Psychiatry related information on GTF2E1

  • Alcohol drinking rats gained significantly less BW than water drinking rats; FI was identical and so FE was less in alcohol-treated animals [2].

High impact information on GTF2E1

  • TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay [3].
  • In contrast, TFIIH preferentially phosphorylates the ctd as well as TFIIE alpha, but not cdk2 [4].
  • Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-alpha [5].
  • The core transcription regulators in archaea and eukaryotes (TFIIB/TFB, TFIIE-alpha and MBF1) and in bacteria (the sigma factors) share no similarity beyond the presence of distinct HTH domains [6].
  • Weight gain, feed efficiency (FE) and serum methionine concentrations were significantly affected by dietary TSAA concentration, but not by dietary choline concentration or the interaction between TSAA and choline [7].

Chemical compound and disease context of GTF2E1


Biological context of GTF2E1

  • Relative food intake (RFI), feed efficiency (FE) and specific growth rate (SGR) were higher in females than in males in all treatments [8].

Anatomical context of GTF2E1

  • Lymphocytes were isolated from male broilers from a single line that were shown to exhibit either low (0.48 +/- 0.02, n = 8) or high (0.68 +/- 0.01, n = 7) feed efficiency (FE) [9].
  • The maltase and sucrase data suggest that VM improved BW and FE of CON poults, in part, by helping to maintain digestive and absorptive functions of the small intestine during the early growth period, but, in the instance of INO poults, VM was not effective in this regard [10].
  • Protein carbonyls were higher in low FE mucosa in tissue homogenate and mitochondrial fraction [11].
  • In contrast, the 0.048% SBL level in the PDH gave inconsistent results for feed efficiency (FE) and brush border enzyme levels [12].

Associations of GTF2E1 with chemical compounds

  • The results provide evidence that MT may affect sexually related growth dimorphism by decreasing food intake and FE in Eurasian perch [8].

Regulatory relationships of GTF2E1


Other interactions of GTF2E1

  • In contrast, while eukaryotic TFIIB and TFIIE-alpha possess forms of the HTH domain that are divergent in sequence, their archaeal counterparts contain typical HTH domains [6].

Analytical, diagnostic and therapeutic context of GTF2E1

  • The purified TFIIE contained equimolar amounts of 57-kDa (TFIIE-alpha) and 34-kDa (TFIIE-beta) polypeptides that were judged to be functional subunits on the basis of their copurification with transcriptional activity and the recovery of activity following renaturation of polypeptides separated by reverse-phase HPLC [13].
  • After sympathectomy, the water drinking group was identical to its own control group for BW gain, FI and FE [2].
  • Two-dimensional gel electrophoresis revealed that the intensities of 25 protein spots from pooled samples of lymphocytes from high and low FE broilers differed by 5-fold or more [9].
  • Feed efficiency (FE) was not determined in Experiment 1, but in Experiment 2, FE from 1 to 14 days of age was impaired by inoculum, irrespective of filtration [14].


  1. Dietary sulfur amino acid requirement of juvenile yellow perch fed the maximum cystine replacement value for methionine. Twibell, R.G., Wilson, K.A., Brown, P.B. J. Nutr. (2000) [Pubmed]
  2. Effect of interscapular brown adipose tissue denervation on body weight and feed efficiency in alcohol drinking rats. Larue-Achagiotis, C., Poussard, A.M., Louis-Sylvestre, J. Physiol. Behav. (1989) [Pubmed]
  3. Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE. Ohkuma, Y., Sumimoto, H., Hoffmann, A., Shimasaki, S., Horikoshi, M., Roeder, R.G. Nature (1991) [Pubmed]
  4. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. Rossignol, M., Kolb-Cheynel, I., Egly, J.M. EMBO J. (1997) [Pubmed]
  5. Analysis of the role of TFIIE in basal transcription and TFIIH-mediated carboxy-terminal domain phosphorylation through structure-function studies of TFIIE-alpha. Ohkuma, Y., Hashimoto, S., Wang, C.K., Horikoshi, M., Roeder, R.G. Mol. Cell. Biol. (1995) [Pubmed]
  6. DNA-binding proteins and evolution of transcription regulation in the archaea. Aravind, L., Koonin, E.V. Nucleic Acids Res. (1999) [Pubmed]
  7. Choline is required by tilapia when methionine is not in excess. Kasper, C.S., White, M.R., Brown, P.B. J. Nutr. (2000) [Pubmed]
  8. Are sex steroids involved in the sexual growth dimorphism in Eurasian perch juveniles? Mandiki, S.N., Houbart, M., Babiak, I., Vandeloise, E., Gardeur, J.N., Kestemont, P. Physiol. Behav. (2004) [Pubmed]
  9. Differential expression of mitochondrial and extramitochondrial proteins in lymphocytes of male broilers with low and high feed efficiency. Lassiter, K., Ojano-Dirain, C., Iqbal, M., Pumford, N.R., Tinsley, N., Lay, J., Liyanage, R., Wing, T., Cooper, M., Bottje, W. Poult. Sci. (2006) [Pubmed]
  10. Responses of turkey poults to virginiamycin as influenced by litter condition and experimentally induced stunting syndrome. Al-Batshan, H.A., Sell, J.L., Piquer, J., Mallarino, E., Soto-Salanova, M.F., Angel, C.R. Poult. Sci. (1992) [Pubmed]
  11. Gene expression in breast muscle and duodenum from low and high feed efficient broilers. Ojano-Dirain, C., Toyomizu, M., Wing, T., Cooper, M., Bottje, W.G. Poult. Sci. (2007) [Pubmed]
  12. Response of turkey poults to soybean lectin levels typically encountered in commercial diets. 1. Effect on growth and nutrient digestibility. Fasina, Y.O., Garlich, J.D., Classen, H.L., Ferket, P.R., Havenstein, G.B., Grimes, J.L., Qureshi, M.A., Christensent, V.L. Poult. Sci. (2004) [Pubmed]
  13. Factors involved in specific transcription by mammalian RNA polymerase II: purification and characterization of general transcription factor TFIIE. Ohkuma, Y., Sumimoto, H., Horikoshi, M., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  14. Evidence that bacteria are not causative agents of stunting syndrome in poults. Sell, J.L., Reynolds, D.L., Jeffrey, M. Poult. Sci. (1992) [Pubmed]
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