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Gene Review

Apex2  -  apurinic/apyrimidinic endonuclease 2

Mus musculus

Synonyms: AP endonuclease 2, APEX nuclease 2, Ape2, Apurinic-apyrimidinic endonuclease 2, C430040P13Rik, ...
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High impact information on Apex2


Biological context of Apex2

  • Much less is known about Ape2, but its importance is emphasized by the growth retardation and dyshematopoiesis accompanied by G2/M arrest phenotype of the APE2-null mice [2].
  • Mutation of the active-site residue Asp 277 to Ala in Ape2 inactivates all these activities [2].


  1. Characterization of the genomic structure and expression of the mouse Apex2 gene. Ide, Y., Tsuchimoto, D., Tominaga, Y., Iwamoto, Y., Nakabeppu, Y. Genomics (2003) [Pubmed]
  2. Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs. Burkovics, P., Szukacsov, V., Unk, I., Haracska, L. Nucleic Acids Res. (2006) [Pubmed]
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