Gene Review:
Alas2 - aminolevulinic acid synthase 2, erythroid
Mus musculus
Synonyms:
5-aminolevulinate synthase, 5-aminolevulinate synthase, erythroid-specific, mitochondrial, 5-aminolevulinic acid synthase 2, ALAS, ALAS-E, ...
- Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload. Nakajima, O., Takahashi, S., Harigae, H., Furuyama, K., Hayashi, N., Sassa, S., Yamamoto, M. EMBO J. (1999)
- Erythroleukemia differentiation. Distinctive responses of the erythroid-specific and the nonspecific delta-aminolevulinate synthase mRNA. Fujita, H., Yamamoto, M., Yamagami, T., Hayashi, N., Sassa, S. J. Biol. Chem. (1991)
- Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization. Ferreira, G.C., Dailey, H.A. J. Biol. Chem. (1993)
- Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria. Schuurmans, M.M., Hoffmann, F., Lindberg, R.L., Meyer, U.A. Hepatology (2001)
- Pre-steady-state reaction of 5-aminolevulinate synthase. Evidence for a rate-determining product release. Hunter, G.A., Ferreira, G.C. J. Biol. Chem. (1999)
- 5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia. Sutherland, G.R., Baker, E., Callen, D.F., Hyland, V.J., May, B.K., Bawden, M.J., Healy, H.M., Borthwick, I.A. Am. J. Hum. Genet. (1988)
- Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. Harigae, H., Nakajima, O., Suwabe, N., Yokoyama, H., Furuyama, K., Sasaki, T., Kaku, M., Yamamoto, M., Sassa, S. Blood (2003)
- Active site of 5-aminolevulinate synthase resides at the subunit interface. Evidence from in vivo heterodimer formation. Tan, D., Ferreira, G.C. Biochemistry (1996)
- Pyridoxine refractory X-linked sideroblastic anemia caused by a point mutation in the erythroid 5-aminolevulinate synthase gene. Furuyama, K., Fujita, H., Nagai, T., Yomogida, K., Munakata, H., Kondo, M., Kimura, A., Kuramoto, A., Hayashi, N., Yamamoto, M. Blood (1997)
- The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation. Sultana, R., Adler, D.A., Edelhoff, S., Carrel, L., Lee, K.H., Chapman, V.C., Willard, H.F., Disteche, C.M. Hum. Mol. Genet. (1995)
- Characterization of the genomic structure and expression of the mouse Apex2 gene. Ide, Y., Tsuchimoto, D., Tominaga, Y., Iwamoto, Y., Nakabeppu, Y. Genomics (2003)
- The role of the erythroid-specific delta-aminolevulinate synthase gene expression in erythroid heme synthesis. Meguro, K., Igarashi, K., Yamamoto, M., Fujita, H., Sassa, S. Blood (1995)
- Light pulse-induced heme and iron-associated transcripts in mouse brain: a microarray analysis. Ben-Shlomo, R., Akhtar, R.A., Collins, B.H., Judah, D.J., Davies, R., Kyriacou, C.P. Chronobiol. Int. (2005)
- Deficient heme and globin synthesis in embryonic stem cells lacking the erythroid-specific delta-aminolevulinate synthase gene. Harigae, H., Suwabe, N., Weinstock, P.H., Nagai, M., Fujita, H., Yamamoto, M., Sassa, S. Blood (1998)
- Regulation of 5-aminolevulinate synthase in mouse erythroleukemic cells is different from that in liver. Elferink, C.J., Sassa, S., May, B.K. J. Biol. Chem. (1988)
- Biphasic ordered induction of heme synthesis in differentiating murine erythroleukemia cells: role of erythroid 5-aminolevulinate synthase. Lake-Bullock, H., Dailey, H.A. Mol. Cell. Biol. (1993)
- Transient state kinetic investigation of 5-aminolevulinate synthase reaction mechanism. Zhang, J., Ferreira, G.C. J. Biol. Chem. (2002)
- Differential induction responses of delta-aminolevulinate synthase mRNAs during erythroid differentiation: use of nonradioactive in situ hybridization. Mitani, K., Fujita, H., Hayashi, N., Yamamoto, M., Sassa, S. Am. J. Hematol. (1992)
- Transcriptional regulation of the murine erythroid-specific 5-aminolevulinate synthase gene. Kramer, M.F., Gunaratne, P., Ferreira, G.C. Gene (2000)
- Fine genetic mapping of the Hyp mutation on mouse chromosome X. Du, L., Desbarats, M., Cornibert, S., Malo, D., Ecarot, B. Genomics (1996)
- Effect of Griseofulvin on 5-aminolevulinate synthase and on ferrochelatase in mouse liver neoplastic nodules. Denk, H., Kalt, R., Abdelfattach-Gad, M., Meyer, U.A. Cancer Res. (1981)
- Protein tyrosine phosphatase-dependent activation of beta-globin and delta-aminolevulinic acid synthase genes in the camptothecin-induced IW32 erythroleukemia cell differentiation. Wang, M.C., Liu, J.H., Wang, F.F. Mol. Pharmacol. (1997)
- Circular permutation of 5-aminolevulinate synthase. Mapping the polypeptide chain to its function. Cheltsov, A.V., Barber, M.J., Ferreira, G.C. J. Biol. Chem. (2001)
- Animal models for X-linked sideroblastic anemia. Yamamoto, M., Nakajima, O. Int. J. Hematol. (2000)