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Gene Review

BRPF1  -  bromodomain and PHD finger containing, 1

Homo sapiens

Synonyms: BR140, Bromodomain and PHD finger-containing protein 1, Peregrin, Protein Br140
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High impact information on BRPF1

  • The latter can be arranged in three zinc fingers and shows homology to a domain within the protein Br140 (peregrin) [1].
  • These structures have been found to be conserved in sequence and position in three other proteins, AF17, BR140, and a previously unrecognized Caenorhabditis elegans gene, provisionally named CEZF [2].
  • To assess the potential involvement of BR140 in chromosome translocations in leukaemia, the chromosomal location of the BR140 gene has been determined by using several independent methods [3].
  • The BR140 gene encodes a 140 kDa protein of unknown function that contains a putative zinc finger domain, a leucine zipper region, and, in addition, a bromo domain [3].
  • The Br140 protein was initially identified due to its co-purification with an integrin [4].

Biological context of BRPF1


Analytical, diagnostic and therapeutic context of BRPF1

  • At the present time, we are engaged in the introduction of further methods, originally destined for clinical praxis, i.e. electrooculography (for laboratory purposes worked out by Manák) and electroretinography (worked out by Peregrín and Svĕrák) [5].


  1. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Prasad, R., Leshkowitz, D., Gu, Y., Alder, H., Nakamura, T., Saito, H., Huebner, K., Berger, R., Croce, C.M., Canaani, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Chaplin, T., Ayton, P., Bernard, O.A., Saha, V., Della Valle, V., Hillion, J., Gregorini, A., Lillington, D., Berger, R., Young, B.D. Blood (1995) [Pubmed]
  3. Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25. Gregorini, A., Sahin, F.I., Lillington, D.M., Meerabux, J., Saha, V., McCullagh, P., Bocci, M., Menevse, S., Papa, S., Young, B.D. Genes Chromosomes Cancer (1996) [Pubmed]
  4. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. Thompson, K.A., Wang, B., Argraves, W.S., Giancotti, F.G., Schranck, D.P., Ruoslahti, E. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  5. Physiological and psychological functions of human organism under different light conditions. Melichercík, J., Krtilová, A. Czechoslovak medicine. (1981) [Pubmed]
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