Disease relevance of PLEKHF1

• Vesico-ureteric reflux is emerging as the most common urological finding in infants with antenatal hydronephrosis and is likely to be missed if kidneys with APPD of less than 10 mm are not further investigated [1].

Psychiatry related information on PLEKHF1

• Thirty-three cases retained their index diagnosis of APPD, while 12 cases required diagnostic revision: 10 to bipolar affective disorder and the rest to unspecified non-organic psychosis [2].
• OBJECTIVE: Acute polymorphic psychotic disorder without symptoms of schizophrenia (APPD) in ICD-10 is unique in many characteristics [2].

High impact information on PLEKHF1

• A highly significant correlation between the accumulation of IMP and the activity of ADA in fresh erythrocytes (r = 0.93; p = less than 0.001) and in erythrocytes incubated in APPD medium (r = 0.97; p = less than 0.001) was found [3].
• Fresh human red cells were incubated for 2 hours in a medium containing adenosine, pyruvate and inorganic phosphate (APP medium), or in APP medium supplemented with 10(-4) M dipyridamole (APPD medium) [4].
• An investigation was carried out on the penetration of [8-14C]adenine into fresh human red blood cells and of adenine incorporation into hypoxanthine nucleotides of red blood cells incubated in: 1) a medium containing adenosine, pyruvate, inorganic phosphate and NaCl, and 2) APP medium containing 1 X 10(-4) M dipyridamole (APPD medium) [5].

Anatomical context of PLEKHF1

• The inhibition of nucleotide synthesis and incorporation of the isotope into them did not apply to IMP, whose content--following erythrocyte incubation in APPD medium--increased 3.5 times, i.e. from 1.52 to 5.30 mumole/g Hb [5].

Associations of PLEKHF1 with chemical compounds

• Erythrocyte incubation in APPD medium reduced ITP synthesis by about 53% relative to its synthesis observed after erythrocyte incubation in APP medium equal to 1.40 mumole per g Hb [5].

References