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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hydronephrosis


Psychiatry related information on Hydronephrosis


High impact information on Hydronephrosis


Chemical compound and disease context of Hydronephrosis


Biological context of Hydronephrosis

  • The purpose of this study was to evaluate the feasibility of modifying diuresis renography by the simultaneous administration of 99mTc-mercaptoacetyltriglycine (MAG3) and furosemide in the investigation of hydronephrosis and hydroureteronephrosis in infants and children [17].
  • BACKGROUND: In the neonatal period, angiotensin II (Ang II) is up-regulated and induces a timely development of the renal pelvis and ureteral peristalsis, thereby protecting the kidney from hydronephrosis [18].
  • When pregnant dams were administered with TCDD by gavage, at a dose of 40 microg/kg body weight at gestation day 12.5, none of the Ahr-null mutant foetuses were sensitive to the teratogenic effects of TCDD, although almost all wild-type foetuses suffered from cleft palate and hydronephrosis [19].
  • MATERIALS AND METHODS: We performed a retrospective multicenter review of Society for Fetal Urology data sheets completed for each patient in whom prenatal hydronephrosis was proved to be postnatal vesicoureteral reflux from 1993 to 1998 [20].
  • In heterozygous Ahr+/- genotypes, nearly all foetuses suffered from hydronephrosis in response to TCDD treatment, while haplo-insufficiency was observed in the incidence of cleft palate [19].

Anatomical context of Hydronephrosis


Gene context of Hydronephrosis


Analytical, diagnostic and therapeutic context of Hydronephrosis


  1. Curable hypertension with unilateral hydronephrosis. Studies on the role of circulating renin. Weidmann, P., Beretta-Piccoli, C., Hirsch, D., Reubi, F.C., Massry, S.G. Ann. Intern. Med. (1977) [Pubmed]
  2. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Moriguchi, T., Motohashi, H., Hosoya, T., Nakajima, O., Takahashi, S., Ohsako, S., Aoki, Y., Nishimura, N., Tohyama, C., Fujii-Kuriyama, Y., Yamamoto, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. McDill, B.W., Li, S.Z., Kovach, P.A., Ding, L., Chen, F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. Congenital malformations associated with anencephaly and iniencephaly. David, T.J., Nixon, A. J. Med. Genet. (1976) [Pubmed]
  5. SGP-2 expression as a genetic marker of progressive cellular pathology in experimental hydronephrosis. Connor, J., Buttyan, R., Olsson, C.A., D'Agati, V., O'Toole, K., Sawczuk, I.S. Kidney Int. (1991) [Pubmed]
  6. Trisomy 8 mosaicism syndrome. Fineman, R.M., Ablow, R.C., Howard, R.O., Albright, J., Breg, W.R. Pediatrics (1975) [Pubmed]
  7. Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Batourina, E., Choi, C., Paragas, N., Bello, N., Hensle, T., Costantini, F.D., Schuchardt, A., Bacallao, R.L., Mendelsohn, C.L. Nat. Genet. (2002) [Pubmed]
  8. Maternal outcome after open fetal surgery. A review of the first 17 human cases. Longaker, M.T., Golbus, M.S., Filly, R.A., Rosen, M.A., Chang, S.W., Harrison, M.R. JAMA (1991) [Pubmed]
  9. Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. Okazaki, T., Otaka, Y., Wang, J., Hiai, H., Takai, T., Ravetch, J.V., Honjo, T. J. Exp. Med. (2005) [Pubmed]
  10. Enhancing effect on N-nitrosodimethylamine-induced tumorigenesis by unilateral hydronephrosis. Ohmori, T. J. Natl. Cancer Inst. (1984) [Pubmed]
  11. Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits. Inflammatory response involving fibroblasts and mononuclear cells. Okegawa, T., Jonas, P.E., DeSchryver, K., Kawasaki, A., Needleman, P. J. Clin. Invest. (1983) [Pubmed]
  12. Modulation of N-nitrosodimethylamine kidney tumorigenesis by unilateral hydronephrosis and multiple putrescine administrations. Ohmori, T., Tabei, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  13. Uncompensated polyuria in a mouse model of Bartter's syndrome. Takahashi, N., Chernavvsky, D.R., Gomez, R.A., Igarashi, P., Gitelman, H.J., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  14. Effect of endogenously produced leukotrienes and thromboxane on renal vascular resistance in rabbit hydronephrosis. Albrightson, C.R., Evers, A.S., Griffin, A.C., Needleman, P. Circ. Res. (1987) [Pubmed]
  15. Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. Lochard, N., Silversides, D.W., van Kats, J.P., Mercure, C., Reudelhuber, T.L. J. Biol. Chem. (2003) [Pubmed]
  16. Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis. Yosypiv, I.V., Schroeder, M., El-Dahr, S.S. J. Am. Soc. Nephrol. (2006) [Pubmed]
  17. F+0 diuresis renography in infants and children. Wong, D.C., Rossleigh, M.A., Farnsworth, R.H. J. Nucl. Med. (1999) [Pubmed]
  18. Salutary role for angiotensin in partial urinary tract obstruction. Fujinaka, H., Miyazaki, Y., Matsusaka, T., Yoshida, H., Fogo, A.B., Inagami, T., Ichikawa, I. Kidney Int. (2000) [Pubmed]
  19. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T.N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., Fujii-Kuriyama, Y. Genes Cells (1997) [Pubmed]
  20. A multicenter outcomes analysis of patients with neonatal reflux presenting with prenatal hydronephrosis. Herndon, C.D., McKenna, P.H., Kolon, T.F., Gonzales, E.T., Baker, L.A., Docimo, S.G. J. Urol. (1999) [Pubmed]
  21. Abnormal dimercapto-succinic acid scans predict an increased risk of breakthrough infection in children with vesicoureteral reflux. Mingin, G.C., Nguyen, H.T., Baskin, L.S., Harlan, S. J. Urol. (2004) [Pubmed]
  22. The correlation of serum carbohydrate antigen 19-9 with benign hydronephrosis. Suzuki, K., Muraishi, O., Tokue, A. J. Urol. (2002) [Pubmed]
  23. Erythropoietin in renal and hepatic lymph of conscious ewes. Murphy, M.J., MacPherson, G.G., Camiscoli, J.F., Gordon, A.S. Exp. Hematol. (1977) [Pubmed]
  24. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. Yang, B., Ma, T., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  25. APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer. Sak, S.C., Harnden, P., Johnston, C.F., Paul, A.B., Kiltie, A.E. Clin. Cancer Res. (2005) [Pubmed]
  26. Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo. Abbott, B.D., Probst, M.R. Dev. Dyn. (1995) [Pubmed]
  27. Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha. Bryant, P.L., Schmid, J.E., Fenton, S.E., Buckalew, A.R., Abbott, B.D. Toxicol. Sci. (2001) [Pubmed]
  28. Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency. Beamer, W.G., Sweet, H.O., Bronson, R.T., Shire, J.G., Orth, D.N., Davisson, M.T. J. Endocrinol. (1994) [Pubmed]
  29. Predicting the success of retrograde stenting for managing ureteral obstruction. Yossepowitch, O., Lifshitz, D.A., Dekel, Y., Gross, M., Keidar, D.M., Neuman, M., Livne, P.M., Baniel, J. J. Urol. (2001) [Pubmed]
  30. Re: Optimal timing of initial postnatal ultrasonography in newborns with prenatal hydronephrosis. Docimo, S.G. J. Urol. (2003) [Pubmed]
  31. Stenosis of the afferent antireflux valve in the Kock pouch continent urinary diversion: diagnosis and management. Stein, J.P., Huffman, J.L., Freeman, J.A., Boyd, S.D., Lieskovsky, G., Skinner, D.G. J. Urol. (1994) [Pubmed]
  32. Dynamic renal scintigraphy in children with vesicoureteral reflux and suspected coexisting ureteropelvic junction obstruction. Stauss, J., Connolly, L.P., Connolly, S.A., Zurakowski, D., Treves, S.T., Peters, C.A. J. Urol. (2003) [Pubmed]
  33. Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: Part 1, functional assessment. Jones, R.A., Easley, K., Little, S.B., Scherz, H., Kirsch, A.J., Grattan-Smith, J.D. AJR. American journal of roentgenology. (2005) [Pubmed]
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