Gene Review:
ATF4 - activating transcription factor 4
Homo sapiens
Synonyms:
Activating transcription factor 4, CREB-2, CREB2, Cyclic AMP-dependent transcription factor ATF-4, Cyclic AMP-responsive element-binding protein 2, ...
- Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. He, C.H., Gong, P., Hu, B., Stewart, D., Choi, M.E., Choi, A.M., Alam, J. J. Biol. Chem. (2001)
- Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. Lim, C., Sohn, H., Gwack, Y., Choe, J. J. Gen. Virol. (2000)
- Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines. Tanabe, M., Izumi, H., Ise, T., Higuchi, S., Yamori, T., Yasumoto, K., Kohno, K. Cancer Res. (2003)
- Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Reddy, T.R., Tang, H., Li, X., Wong-Staal, F. Oncogene (1997)
- Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. Yu, V.W., Gauthier, C., St-Arnaud, R. Ann. N. Y. Acad. Sci. (2006)
- The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Sayer, J.A., Otto, E.A., O'Toole, J.F., Nurnberg, G., Kennedy, M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett, B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J., Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S., Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R., Hildebrandt, F. Nat. Genet. (2006)
- SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Dobreva, G., Chahrour, M., Dautzenberg, M., Chirivella, L., Kanzler, B., Fariñas, I., Karsenty, G., Grosschedl, R. Cell (2006)
- TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K., Hayashi, H. EMBO J. (2005)
- Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. Roybal, C.N., Yang, S., Sun, C.W., Hurtado, D., Vander Jagt, D.L., Townes, T.M., Abcouwer, S.F. J. Biol. Chem. (2004)
- Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. Averous, J., Bruhat, A., Jousse, C., Carraro, V., Thiel, G., Fafournoux, P. J. Biol. Chem. (2004)
- The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. Roybal, C.N., Hunsaker, L.A., Barbash, O., Vander Jagt, D.L., Abcouwer, S.F. J. Biol. Chem. (2005)
- Mitosin/CENP-F as a negative regulator of activating transcription factor-4. Zhou, X., Wang, R., Fan, L., Li, Y., Ma, L., Yang, Z., Yu, W., Jing, N., Zhu, X. J. Biol. Chem. (2005)
- Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). De Angelis, R., Iezzi, S., Bruno, T., Corbi, N., Di Padova, M., Floridi, A., Fanciulli, M., Passananti, C. FEBS Lett. (2003)
- GABA(B) receptors couple directly to the transcription factor ATF4. Vernon, E., Meyer, G., Pickard, L., Dev, K., Molnar, E., Collingridge, G.L., Henley, J.M. Mol. Cell. Neurosci. (2001)
- Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4). Gachon, F., Thebault, S., Peleraux, A., Devaux, C., Mesnard, J.M. Mol. Cell. Biol. (2000)
- ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Kawai, T., Matsumoto, M., Takeda, K., Sanjo, H., Akira, S. Mol. Cell. Biol. (1998)
- Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Obeng, E.A., Carlson, L.M., Gutman, D.M., Harrington, W.J., Lee, K.P., Boise, L.H. Blood (2006)
- ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. Siu, F., Bain, P.J., LeBlanc-Chaffin, R., Chen, H., Kilberg, M.S. J. Biol. Chem. (2002)
- Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Igarashi, T., Izumi, H., Uchiumi, T., Nishio, K., Arao, T., Tanabe, M., Uramoto, H., Sugio, K., Yasumoto, K., Sasaguri, Y., Wang, K.Y., Otsuji, Y., Kohno, K. Oncogene (2007)
- Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. Liang, G., Hai, T. J. Biol. Chem. (1997)
- ATF4 regulates gamma-secretase activity during amino acid imbalance. Mitsuda, T., Hayakawa, Y., Itoh, M., Ohta, K., Nakagawa, T. Biochem. Biophys. Res. Commun. (2007)
- p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. Lassot, I., Estrabaud, E., Emiliani, S., Benkirane, M., Benarous, R., Margottin-Goguet, F. J. Biol. Chem. (2005)
- Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development. Murphy, P., Kolstø, A. Mech. Dev. (2000)
- Amino acid deprivation and endoplasmic reticulum stress induce expression of multiple activating transcription factor-3 mRNA species that, when overexpressed in HepG2 cells, modulate transcription by the human asparagine synthetase promoter. Pan, Y., Chen, H., Siu, F., Kilberg, M.S. J. Biol. Chem. (2003)
- ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Lassot, I., Ségéral, E., Berlioz-Torrent, C., Durand, H., Groussin, L., Hai, T., Benarous, R., Margottin-Goguet, F. Mol. Cell. Biol. (2001)
- Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Ameri, K., Lewis, C.E., Raida, M., Sowter, H., Hai, T., Harris, A.L. Blood (2004)
- ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes. Magne, L., Blanc, E., Legrand, B., Lucas, D., Barouki, R., Rouach, H., Garlatti, M. J. Hepatol. (2011)
- Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation. Chen, H., Pan, Y.X., Dudenhausen, E.E., Kilberg, M.S. J. Biol. Chem. (2004)
- Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. Ord, D., Ord, T. Biochem. Biophys. Res. Commun. (2005)
- Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence. Chen, C., Dudenhausen, E., Chen, H., Pan, Y.X., Gjymishka, A., Kilberg, M.S. Biochem. J. (2005)
- Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32. Diep, A., Li, C., Klisak, I., Mohandas, T., Sparkes, R.S., Gaynor, R., Lusis, A.J. Genomics (1991)
- Presence of activating transcription factor 4 (ATF4) in the porcine anterior pituitary. Kato, Y., Koike, Y., Tomizawa, K., Ogawa, S., Hosaka, K., Tanaka, S., Kato, T. Mol. Cell. Endocrinol. (1999)