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Gene Review

SMC6  -  structural maintenance of chromosomes 6

Homo sapiens

Synonyms: FLJ22116, SMC protein 6, SMC-6, SMC6L1, Structural maintenance of chromosomes protein 6, ...
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High impact information on SMC6

  • Another complex containing SMC5 and SMC6 is implicated in DNA repair and checkpoint responses [1].
  • We have examined the response of smc6 mutants to the inhibition of DNA replication [2].
  • We show here that both S. pombe and human Smc5 and -6 interact through their hinge domains and that four independent temperature-sensitive mutants of Rad18 (Smc6) are all mutated at the same glycine residue in the hinge region [3].
  • Both the total level of hSMC6 and its phosphorylated form remain constant through the cell cycle [4].
  • Both hSMC5 and hSMC6 proteins are expressed at extremely high levels in the testis and associate with the sex chromosomes in the late stages of meiotic prophase, suggesting a possible role for these proteins in meiosis [4].

Biological context of SMC6

  • Genetic and biochemical studies indicate that Rad60 functions codependently with Smc5 and Smc6, subunits of an SMC (structural maintenance of chromosomes) complex required for recombinational repair [5].


  1. Dynamic molecular linkers of the genome: the first decade of SMC proteins. Losada, A., Hirano, T. Genes Dev. (2005) [Pubmed]
  2. Smc5/6 is required for repair at collapsed replication forks. Ampatzidou, E., Irmisch, A., O'connell, M.J., Murray, J.M. Mol. Cell. Biol. (2006) [Pubmed]
  3. Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex. Sergeant, J., Taylor, E., Palecek, J., Fousteri, M., Andrews, E.A., Sweeney, S., Shinagawa, H., Watts, F.Z., Lehmann, A.R. Mol. Cell. Biol. (2005) [Pubmed]
  4. Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. Taylor, E.M., Moghraby, J.S., Lees, J.H., Smit, B., Moens, P.B., Lehmann, A.R. Mol. Biol. Cell (2001) [Pubmed]
  5. Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Boddy, M.N., Shanahan, P., McDonald, W.H., Lopez-Girona, A., Noguchi, E., Yates III, J.R., Russell, P. Mol. Cell. Biol. (2003) [Pubmed]
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