The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ULBP2  -  UL16 binding protein 2

Homo sapiens

Synonyms: ALCAN-alpha, N2DL-2, N2DL2, NKG2D ligand 2, NKG2DL2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ULBP2

  • We report that ectopic expression of ULBP1 or ULBP2 on murine EL4 or RMA tumor cells elicits potent antitumor responses in syngeneic C57BL/6 and SCID mice [1].
  • Results show that the HIV-1 Nef protein downmodulates cell-surface expression of MICA, ULBP1 and ULBP2, with a stronger effect on the latter molecule [2].
  • Loss of MICA and ULBP2, in contrast to other NKG2DL, may be particularly important in glioma immune escape, and differential regulation of human NKG2DL expression is part of the immunosuppressive properties of human malignant glioma cells [3].

High impact information on ULBP2

  • While ULBP2 binds the activating NK receptor NKG2D, the BB4 moiety binds to CD138, which is overexpressed on a variety of malignancies, including MM [4].
  • We herein show that the survival is ascribable to the deficiency of stress-inducible GPI-linked membrane proteins ULBP1 and ULBP2, which activate NK and T cells [5].
  • Proteolytic shedding of both NKG2D ligands MICA and ULBP2 by tumor cells was strongly enhanced after phorbol 12-myristate 13-acetate treatment and paralleled by a markedly reduced susceptibility to NKG2D-mediated cytotoxicity [6].
  • Here, we now report that ULBP2 molecules are likewise released from tumor cells in a processed soluble form, and that soluble ULBP2 (sULBP2) can be detected in sera of some patients with hematopoietic malignancies [6].
  • MICA and ULBP2 expression decrease with increasing WHO grade of malignancy, while MICB and ULBP1 are expressed independently of tumour grade [3].

Anatomical context of ULBP2


Other interactions of ULBP2

  • Thus, escape from NKG2D-mediated immune surveillance of malignant gliomas in vivo may be promoted by the inhibition of MICA and ULBP2 expression via an autocrine TGF-beta loop and by MP-dependent shedding from the cell surface [3].


  1. ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15. Sutherland, C.L., Rabinovich, B., Chalupny, N.J., Brawand, P., Miller, R., Cosman, D. Blood (2006) [Pubmed]
  2. Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity. Cerboni, C., Neri, F., Casartelli, N., Zingoni, A., Cosman, D., Rossi, P., Santoni, A., Doria, M. J. Gen. Virol. (2007) [Pubmed]
  3. TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells. Eisele, G., Wischhusen, J., Mittelbronn, M., Meyermann, R., Waldhauer, I., Steinle, A., Weller, M., Friese, M.A. Brain (2006) [Pubmed]
  4. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. von Strandmann, E.P., Hansen, H.P., Reiners, K.S., Schnell, R., Borchmann, P., Merkert, S., Simhadri, V.R., Draube, A., Reiser, M., Purr, I., Hallek, M., Engert, A. Blood (2006) [Pubmed]
  5. Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP. Hanaoka, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Mitsuya, H., Nakakuma, H. Blood (2006) [Pubmed]
  6. Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Waldhauer, I., Steinle, A. Cancer Res. (2006) [Pubmed]
  7. Genomic organization and evolution of the ULBP genes in cattle. Larson, J.H., Marron, B.M., Beever, J.E., Roe, B.A., Lewin, H.A. BMC Genomics (2006) [Pubmed]
  8. Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma. Raffaghello, L., Prigione, I., Airoldi, I., Camoriano, M., Levreri, I., Gambini, C., Pende, D., Steinle, A., Ferrone, S., Pistoia, V. Neoplasia (2004) [Pubmed]
WikiGenes - Universities