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Gene Review

AAO3  -  abscisic-aldehyde oxidase

Arabidopsis thaliana

Synonyms: ABSCISIC ALDEHYDE OXIDASE 3, AOdelta, Aldehyde oxidase delta, Arabidopsis thaliana aldehyde oxidase 3, At-AO3, ...
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Disease relevance of AAO3

  • When the rosette leaves were detached and exposed to dehydration, AAO3 mRNA expression increased rapidly within 3 h of the treatment [1].

High impact information on AAO3

  • We thus conclude that the ABA-deficient mutant is impaired in the AAO3 gene and that the gene product, AOdelta, is an aldehyde oxidase that catalyzes the last step of ABA biosynthesis in Arabidopsis, specifically in rosette leaves [2].
  • The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves [2].
  • Spatial expression patterns of the AtABA2 and AAO3 genes, responsible for last two steps of ABA biosynthesis, were distinct from that of the GA biosynthesis gene, AtGA3ox2, in both imbibed and developing seeds, suggesting that biosynthesis of ABA and GA in seeds occurs in different cell types [3].
  • Taken together, these results indicate that AAO3 gene product plays a major role in seed ABA biosynthesis [4].
  • Indeed, molecular characterization of the aao3-2 mutant revealed a T-DNA insertional mutation that abolished the transcription of AAO3 gene, while sequence analysis of AAO3 in aao3-3 mutant revealed a deletion of three nucleotides and several missense mutations [4].

Other interactions of AAO3


Analytical, diagnostic and therapeutic context of AAO3


  1. Abscisic aldehyde oxidase in leaves of Arabidopsis thaliana. Seo, M., Koiwai, H., Akaba, S., Komano, T., Oritani, T., Kamiya, Y., Koshiba, T. Plant J. (2000) [Pubmed]
  2. The Arabidopsis aldehyde oxidase 3 (AAO3) gene product catalyzes the final step in abscisic acid biosynthesis in leaves. Seo, M., Peeters, A.J., Koiwai, H., Oritani, T., Marion-Poll, A., Zeevaart, J.A., Koornneef, M., Kamiya, Y., Koshiba, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Seo, M., Hanada, A., Kuwahara, A., Endo, A., Okamoto, M., Yamauchi, Y., North, H., Marion-Poll, A., Sun, T.P., Koshiba, T., Kamiya, Y., Yamaguchi, S., Nambara, E. Plant J. (2006) [Pubmed]
  4. Two new alleles of the abscisic aldehyde oxidase 3 gene reveal its role in abscisic acid biosynthesis in seeds. González-Guzmán, M., Abia, D., Salinas, J., Serrano, R., Rodríguez, P.L. Plant Physiol. (2004) [Pubmed]
  5. Comparative studies on the Arabidopsis aldehyde oxidase (AAO) gene family revealed a major role of AAO3 in ABA biosynthesis in seeds. Seo, M., Aoki, H., Koiwai, H., Kamiya, Y., Nambara, E., Koshiba, T. Plant Cell Physiol. (2004) [Pubmed]
  6. Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress. Barrero, J.M., Rodríguez, P.L., Quesada, V., Piqueras, P., Ponce, M.R., Micol, J.L. Plant Cell Environ. (2006) [Pubmed]
  7. Tissue-specific localization of an abscisic acid biosynthetic enzyme, AAO3, in Arabidopsis. Koiwai, H., Nakaminami, K., Seo, M., Mitsuhashi, W., Toyomasu, T., Koshiba, T. Plant Physiol. (2004) [Pubmed]
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