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Gene Review:

NCED3 - 9-cis-epoxycarotenoid dioxygenase NCED3

Arabidopsis thaliana

Synonyms: 9-CIS-EPOXYCAROTENOID DIOXYGENASE, ATNCED3, SALT TOLERANT 1, SIS7, STO1, ...

Wan, X.R. et al., Ruggiero, B. et al., Tan, B.C. et al., Han, S.Y. et al., Ko, J.H. et al., et al.

Ruggiero, Koiwa, Manabe, Quist, Inan, Saccardo, Joly, Hasegawa, Bressan, Maggio,

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Disease relevance of NCED3

Induction of NCED3 (the gene that encodes the rate-limiting enzyme in ABA biosynthesis) by polyethylene glycol-mediated dehydration and ABA accumulation are reduced by this mutation [1].
Ectopic expression of AhNCED1 gene in 129B08/nced3 mutant Arabidopsis (with impaired AtNCED3 gene involved in ABA biosynthesis under water stress) driven by the AtNCED3 promoter restores its ability to accumulate ABA during drought stress, and reverts its hypersensitivity to nonionic osmotic stress and soil drought [2].

High impact information on NCED3

When subjected to a drought treatment, transcriptional upregulation of a key ABA-biosynthesis gene, AtNCED3, was much faster and stronger in 35S::XERICO plants compared with WT plants [3].
Analysis of the amino acid sequence revealed that STO1 encodes a 9-cis-epoxicarotenoid dioxygenase (similar to 9-cis-epoxicarotenoid dioxygenase GB:AAF26356 [Phaseolus vulgaris] and to NCED3 GB:AB020817 [Arabidopsis]), a key enzyme in the abscisic acid (ABA) biosynthetic pathway [4].
Uncoupling the effects of abscisic acid on plant growth and water relations. Analysis of sto1/nced3, an abscisic acid-deficient but salt stress-tolerant mutant in Arabidopsis [4].
In higher plants, the ABA biosynthesis pathway involves the oxidative cleavage of 9-cis-epoxycarotenoids, which may be the key regulatory step in the pathway catalyzed by 9-cis-epoxycarotenoid dioxygenase (NCED) [5].
AtNCED2, AtNCED3, and AtNCED6 are found in both stroma and thylakoid membrane-bound compartments [6].

Chemical compound and disease context of NCED3

Regulation of ABA level and water-stress tolerance of Arabidopsis by ectopic expression of a peanut 9-cis-epoxycarotenoid dioxygenase gene [2].

Biological context of NCED3

By contrast, antisense suppression and disruption of AtNCED3 gave a drought-sensitive phenotype [7].

Associations of NCED3 with chemical compounds

Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress [8].
A key regulated step in abscisic acid (ABA) biosynthesis in plants is catalyzed by 9-cis epoxycarotenoid dioxygenase (NCED), which cleaves 9-cis xanthophylls to xanthoxin, a precursor of ABA [6].
The GST (glutathione S-transferase)-fused protein indicates a 9-cis-epoxycarotenoid dioxygenase activity, which catalyzes the cleavage of 9-cis-epoxycarotenoid [9].

Other interactions of NCED3

AtNCED5, AtNCED6, AtNCED9, and AtNCED3 contribute to expression in developing seeds with high levels of AtNCED6 present at an early stage [6].

References

HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants. Zhu, J., Verslues, P.E., Zheng, X., Lee, B.H., Zhan, X., Manabe, Y., Sokolchik, I., Zhu, Y., Dong, C.H., Zhu, J.K., Hasegawa, P.M., Bressan, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Regulation of ABA level and water-stress tolerance of Arabidopsis by ectopic expression of a peanut 9-cis-epoxycarotenoid dioxygenase gene. Wan, X.R., Li, L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Upregulation of an Arabidopsis RING-H2 gene, XERICO, confers drought tolerance through increased abscisic acid biosynthesis. Ko, J.H., Yang, S.H., Han, K.H. Plant J. (2006) [Pubmed]
Uncoupling the effects of abscisic acid on plant growth and water relations. Analysis of sto1/nced3, an abscisic acid-deficient but salt stress-tolerant mutant in Arabidopsis. Ruggiero, B., Koiwa, H., Manabe, Y., Quist, T.M., Inan, G., Saccardo, F., Joly, R.J., Hasegawa, P.M., Bressan, R.A., Maggio, A. Plant Physiol. (2004) [Pubmed]
A novel inhibitor of 9-cis-epoxycarotenoid dioxygenase in abscisic acid biosynthesis in higher plants. Han, S.Y., Kitahata, N., Sekimata, K., Saito, T., Kobayashi, M., Nakashima, K., Yamaguchi-Shinozaki, K., Shinozaki, K., Yoshida, S., Asami, T. Plant Physiol. (2004) [Pubmed]
Molecular characterization of the Arabidopsis 9-cis epoxycarotenoid dioxygenase gene family. Tan, B.C., Joseph, L.M., Deng, W.T., Liu, L., Li, Q.B., Cline, K., McCarty, D.R. Plant J. (2003) [Pubmed]
Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis. Iuchi, S., Kobayashi, M., Taji, T., Naramoto, M., Seki, M., Kato, T., Tabata, S., Kakubari, Y., Yamaguchi-Shinozaki, K., Shinozaki, K. Plant J. (2001) [Pubmed]
Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress. Barrero, J.M., Rodríguez, P.L., Quesada, V., Piqueras, P., Ponce, M.R., Micol, J.L. Plant Cell Environ. (2006) [Pubmed]
A stress-inducible gene for 9-cis-epoxycarotenoid dioxygenase involved in abscisic acid biosynthesis under water stress in drought-tolerant cowpea. Iuchi, S., Kobayashi, M., Yamaguchi-Shinozaki, K., Shinozaki, K. Plant Physiol. (2000) [Pubmed]

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