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Gene Review

SF3A2  -  splicing factor 3a, subunit 2, 66kDa

Homo sapiens

Synonyms: PRP11, PRPF11, Prp11, SAP 62, SAP62, ...
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Disease relevance of SF3A2

  • Ectopic expression experiments using each SF3a subunit in N1E 115 neuroblastoma cells reveals that SF3a66 alone can induce neurite extension, suggesting that SF3a66 functions in the regulation of cell morphology [1].

High impact information on SF3A2

  • Unlike PRP11, SAP 62 contains 22 proline-rich heptapeptide repeats at the carboxyl-terminus [2].
  • Both PRP11 and SAP 62 associate stably with the spliceosome, contain a single zinc finger, and display significant amino acid sequence similarity [2].
  • We have analyzed the function of individual subunits of human SF3a (SF3a60, SF3a66, and SF3a120) by testing recombinant proteins, expressed in insect cells, in various in vitro assays [3].
  • RNase protection analysis shows the majority of Sap62 transcripts use an uncommon polyadenylation signal (ATTAAA) lying in the intragenic region, 87 bp 3' of the TGA [4].
  • This analysis also shows that Sap62 is transcribed in all tissues examined, whereas specific Amh transcription initiating 10 bp 5' of the ATG is limited to the developing testis of the fetus from 11.5 days post coitum and in the ovary from 3 days post partum [4].

Biological context of SF3A2

  • Here, we report a possible non-canonical function of a well-characterized RNA-splicing factor, SF3a66 [1].
  • Likewise, there was no sequence homology to an SF3A2 sequence within the first 3200 bp upstream of the sb-AMH translation start site [5].

Anatomical context of SF3A2


Analytical, diagnostic and therapeutic context of SF3A2


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