Disease relevance of Rpl19

• By fluorescence in situ hybridization analysis, the position of the human RPL19 gene has been sublocalized to 17q11 and may be coamplified with the erbB-2 gene in human breast cancer cells [1].

High impact information on Rpl19

• Tyrphostin AG18 did not affect mRNA species that are not FSH inducible, such as the ribosomal protein L19, or the constitutively expressed low levels of steroid 5 alpha-reductase mRNA [2].
• The DNA sequences of the entire rat RPL19 gene and the 5' end of the human RPL19 gene have been determined [1].
• Both rat and human RPL19 genes have 5' ends associated with CpG islands [1].
• The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region [1].
• A promoter deletion analysis of the rat RPL19 gene suggests that this promoter may differ from those of all previously characterized ribosomal protein genes in requiring far upstream sequences for efficient gene expression [1].

Biological context of Rpl19

• In this study, the expression of various housekeeping genes (18S rRNA [18S], glyceraldehydes-3-phosphate dehydrogenase [G3PDH], beta-glucuronidase [BGLU], histone H4 [HH4], ribosomal protein L19 [RPL19] and cyclophilin [CY]) was investigated during fetal rat brain development using semi-quantitative RT-PCR at 16, 19 and 21 days gestation [3].
• The mammalian genome contains a high proportion of processed pseudogenes corresponding to ribosomal protein L19 [4].

References