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Hist1h4b  -  histone cluster 1, H4b

Rattus norvegicus

Synonyms: H1ft, H4ft, Hist1h4m, Hist4, Hist4h4, ...
 
 
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Disease relevance of Hist1h4b

 

High impact information on Hist1h4b

 

Biological context of Hist1h4b

 

Anatomical context of Hist1h4b

  • Correlation between the expression of the histone H4 mRNA variant H4-v.1 and the levels of histone H4-(86-100) and H4-(89-102) (OGP) in various rat tissues and alveolar macrophages [11].
  • A unique subspecies of histone H4 mRNA from rat myoblasts contains poly(A) [12].
  • FGF2 not only induced p21 protein expression in proliferating chondrocytes in mouse fetal limbs cultured in vitro but also decreased their proliferation as assessed by the expression of histone H4 mRNA, a marker for cells in S phase [13].
  • Active expression of the OC gene in mature osteoblasts and confluent ROS 17/2.8 cells is functionally linked to preferential acetylation of histone H4 and, to a lesser extent, to acetylation of histone H3 [14].
  • Thus, the in vivo hyperacetylation of histone H4 which occurs in elongating spermatids is a physiological event which occurs during the relatively short time period when the entire complement of histones is replaced by more basic, protamine-like proteins, and therefore must be one of the key steps in this dramatic protein transition [15].
 

Associations of Hist1h4b with chemical compounds

 

Other interactions of Hist1h4b

  • No enhancement of the mRNA expression of several genes required for entrance of prostatic glandular cells into the S-phase of the proliferative cycle (i.e. histone-H4, c-fos, p53, and ornithine decarboxylase) occurred during androgen ablation-induced programmed death of these cells [19].
  • Using chromatin immunoprecipitation assays, we show that histone H4 acetylation increases over a 1.7 kb region of the IRF-1 promoter in early G(1) and again at the G(1)/S transition in response to PRL stimulation [20].
  • Addition of acidic FGF during the proliferative phase (days 7-8) enhanced histone H4, osteopontin, type I collagen, and TGF-beta mRNA levels, which are coupled to proliferating osteoblasts, and blocked the normal developmental increase in alkaline phosphatase and osteocalcin gene expression and calcium accumulation [21].
  • Additionally, the gel reveals two protein bands, one ahead of histone H2B and another ahead of histone H4, that are diminished or missing from the inactive chromatin [22].
  • The initial response to neuronal injury, within the 3 days post-injury, consisted of chromatin condensation, reduction in the expression level of acetylated histone H4, accumulation of perichromatin granules, reorganization of splicing factors in prominent nuclear speckles, reduction in the number of Cajal bodies and nucleolar alterations [23].
 

Analytical, diagnostic and therapeutic context of Hist1h4b

References

  1. Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity. Bab, I., Gazit, D., Chorev, M., Muhlrad, A., Shteyer, A., Greenberg, Z., Namdar, M., Kahn, A. EMBO J. (1992) [Pubmed]
  2. Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures. Pockwinse, S.M., Wilming, L.G., Conlon, D.M., Stein, G.S., Lian, J.B. J. Cell. Biochem. (1992) [Pubmed]
  3. Histone acetyltransferase activity in rat hepatomas. Grunicke, H.H., Yamada, Y., Natsumeda, Y., Helliger, W., Puschendorf, B., Weber, G. J. Cancer Res. Clin. Oncol. (1989) [Pubmed]
  4. Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. Huang, Y., Doherty, J.J., Dingledine, R. J. Neurosci. (2002) [Pubmed]
  5. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Frank, S.R., Schroeder, M., Fernandez, P., Taubert, S., Amati, B. Genes Dev. (2001) [Pubmed]
  6. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. McDonald, O.G., Wamhoff, B.R., Hoofnagle, M.H., Owens, G.K. J. Clin. Invest. (2006) [Pubmed]
  7. Epigenetic programming in the preimplantation rat embryo is disrupted by chronic paternal cyclophosphamide exposure. Barton, T.S., Robaire, B., Hales, B.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. Comparison of the structural organization and expression of germinal and somatic rat histone H4 genes. Wolfe, S.A., Anderson, J.V., Grimes, S.R., Stein, G.S., Stein, J.S. Biochim. Biophys. Acta (1989) [Pubmed]
  9. Biosynthesis of osteogenic growth peptide via alternative translational initiation at AUG85 of histone H4 mRNA. Bab, I., Smith, E., Gavish, H., Attar-Namdar, M., Chorev, M., Chen, Y.C., Muhlrad, A., Birnbaum, M.J., Stein, G., Frenkel, B. J. Biol. Chem. (1999) [Pubmed]
  10. A rat histone H4 gene closely associated with the testis-specific H1t gene. Grimes, S., Weisz-Carrington, P., Daum, H., Smith, J., Green, L., Wright, K., Stein, G., Stein, J. Exp. Cell Res. (1987) [Pubmed]
  11. Correlation between the expression of the histone H4 mRNA variant H4-v.1 and the levels of histone H4-(86-100) and H4-(89-102) (OGP) in various rat tissues and alveolar macrophages. Poirier, R., Lemaire, I., Dumont, M., Leduc, N., Le, H.T., Lemaire, S. Peptides (2005) [Pubmed]
  12. A unique subspecies of histone H4 mRNA from rat myoblasts contains poly(A). Bird, R.C., Jacobs, F.A., Stein, G., Stein, J., Sells, B.H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  13. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. Aikawa, T., Segre, G.V., Lee, K. J. Biol. Chem. (2001) [Pubmed]
  14. Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4. Shen, J., Hovhannisyan, H., Lian, J.B., Montecino, M.A., Stein, G.S., Stein, J.L., Van Wijnen, A.J. Mol. Endocrinol. (2003) [Pubmed]
  15. Hyperacetylation of histone H4 in rat testis spermatids. Grimes, S.R., Henderson, N. Exp. Cell Res. (1984) [Pubmed]
  16. Properties of soluble rat brain histone lysine methyltransferase. Wallwork, J.C., Quick, D.P., Duerre, J.A. J. Biol. Chem. (1977) [Pubmed]
  17. In vitro studies on the methylation of histones in rat brain nuclei. Duerre, J.A., Wallwork, J.C., Quick, D.P., Ford, K.M. J. Biol. Chem. (1977) [Pubmed]
  18. ADP-ribosylation of nuclear proteins in vivo. Identification of histone H2B as a major acceptor for mono- and poly(ADP-ribose) in dimethyl sulfate-treated hepatoma AH 7974 cells. Adamietz, P., Rudolph, A. J. Biol. Chem. (1984) [Pubmed]
  19. Differential gene regulation during programmed death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation. Furuya, Y., Isaacs, J.T. Endocrinology (1993) [Pubmed]
  20. Prolactin activation of IRF-1 transcription involves changes in histone acetylation. Book McAlexander, M., Yu-Lee, L. FEBS Lett. (2001) [Pubmed]
  21. Acidic fibroblast growth factor inhibits osteoblast differentiation in vitro: altered expression of collagenase, cell growth-related, and mineralization-associated genes. Tang, K.T., Capparelli, C., Stein, J.L., Stein, G.S., Lian, J.B., Huber, A.C., Braverman, L.E., DeVito, W.J. J. Cell. Biochem. (1996) [Pubmed]
  22. Studies on the isolated transcriptionally active and inactive chromatin fractions from rat liver nuclei. Yu, F.L., Bender, W. J. Biochem. Biophys. Methods (1995) [Pubmed]
  23. Reorganization of nuclear compartments of type A neurons of trigeminal ganglia in response to inflammatory injury of peripheral nerve endings. Navascues, J., Casafont, I., Villagra, N.T., Lafarga, M., Berciano, M.T. J. Neurocytol. (2004) [Pubmed]
  24. Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. Kyrylenko, S., Kyrylenko, O., Suuronen, T., Salminen, A. Cell. Mol. Life Sci. (2003) [Pubmed]
  25. ADP-ribosylation of nuclear proteins is increased by phenobarbital. Identification of the ADP-ribosylated histone fractions in rat liver nuclei. Bràz, J., Lechner, M.C. FEBS Lett. (1986) [Pubmed]
  26. Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation. Danzi, S., Dubon, P., Klein, I. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  27. p21-activated protein kinase gamma-PAK in pituitary secretory granules phosphorylates prolactin. Tuazon, P.T., Lorenson, M.Y., Walker, A.M., Traugh, J.A. FEBS Lett. (2002) [Pubmed]
 
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