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Gene Review

Srd5a1  -  steroid-5-alpha-reductase, alpha...

Rattus norvegicus

Synonyms: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, S5AR 1, SR type 1, Steroid 5-alpha-reductase 1
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Disease relevance of Srd5a1

  • Furthermore, some of these potent P450(17) alpha inhibitors (27-29) are also powerful inhibitors of steroid 5 alpha-reductase, and others (17 and 19) appear to exhibit strong antiandrogenic activity in cultures of the LNCaP human prostatic cancer cell line [1].
  • BACKGROUND: Steroid 5 alpha-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH) [2].

High impact information on Srd5a1


Chemical compound and disease context of Srd5a1


Biological context of Srd5a1


Anatomical context of Srd5a1


Associations of Srd5a1 with chemical compounds


Other interactions of Srd5a1


Analytical, diagnostic and therapeutic context of Srd5a1


  1. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer. Njar, V.C., Kato, K., Nnane, I.P., Grigoryev, D.N., Long, B.J., Brodie, A.M. J. Med. Chem. (1998) [Pubmed]
  2. FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates. Nakayama, O., Hirosumi, J., Chida, N., Takahashi, S., Sawada, K., Kojo, H., Notsu, Y. Prostate (1997) [Pubmed]
  3. Cell-type-specific expression of rat steroid 5 alpha-reductase isozymes. Berman, D.M., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Feed-forward control of prostate growth: dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase. George, F.W., Russell, D.W., Wilson, J.D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase. Bullock, P., Gemzik, B., Johnson, D., Thomas, P., Parkinson, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes. Hirosumi, J., Nakayama, O., Fagan, T., Sawada, K., Chida, N., Inami, M., Takahashi, S., Kojo, H., Notsu, Y., Okuhara, M. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  7. Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Andersson, S., Russell, D.W. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. LY207320 (6-methylene-4-pregnene-3,20-dione) inhibits testosterone biosynthesis, androgen uptake, 5 alpha-reductase, and produces prostatic regression in male rats. Neubauer, B.L., Best, K.L., Blohm, T.R., Gates, C., Goode, R.L., Hirsch, K.S., Laughlin, M.E., Petrow, V., Smalstig, E.B., Stamm, N.B. Prostate (1993) [Pubmed]
  9. Impact of tamoxifen on peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11, cytochrome P450 3A2, and steroid 5 alpha-reductase. Chang, T.K., Chan, M.M., Holsmer, S.L., Bandiera, S.M., Bellward, G.D. Biochem. Pharmacol. (1996) [Pubmed]
  10. Inhibition of steroid 5 alpha-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450. Sonderfan, A.J., Parkinson, A. Arch. Biochem. Biophys. (1988) [Pubmed]
  11. Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation. Andersson, S., Bishop, R.W., Russell, D.W. J. Biol. Chem. (1989) [Pubmed]
  12. Photoaffinity labeling of steroid 5 alpha-reductase of rat liver and prostate microsomes. Liang, T., Cheung, A.H., Reynolds, G.F., Rasmusson, G.H. J. Biol. Chem. (1985) [Pubmed]
  13. Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. Ram, P.A., Waxman, D.J. J. Biol. Chem. (1990) [Pubmed]
  14. Immunocytochemical localization of 4-ene steroid 5 alpha-reductase type 1 along the rat epididymis during postnatal development. Viger, R.S., Robaire, B. Endocrinology (1994) [Pubmed]
  15. Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard. Chang, T.K., Waxman, D.J. Cancer Res. (1993) [Pubmed]
  16. Tyrosine kinase inhibitor AG18 arrests follicle-stimulating hormone-induced granulosa cell differentiation: use of reverse transcriptase-polymerase chain reaction assay for multiple messenger ribonucleic acids. Orly, J., Rei, Z., Greenberg, N.M., Richards, J.S. Endocrinology (1994) [Pubmed]
  17. NADPH-cytochrome P-450 reductase is not a component of the liver microsomal steroid 5-alpha reductase. Cheng, K.C., Wang, R.W., Lu, A.Y. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  18. Inhibition of pyridine-nucleotide-dependent enzymes by pyrazoles. Synthesis and enzymology of a novel A-ring pyrazole steroid. Holt, D.A., Levy, M.A., Brandt, M., Metcalf, B.W. Steroids (1986) [Pubmed]
  19. Four-amino acid segment in steroid 5 alpha-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. Thigpen, A.E., Russell, D.W. J. Biol. Chem. (1992) [Pubmed]
  20. Expression of 4-ene steroid 5 alpha-reductase messenger ribonucleic acid in the rat epididymis during postnatal development. Viger, R.S., Robaire, B. Endocrinology (1992) [Pubmed]
  21. Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation. Chang, T.K., Bellward, G.D. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  22. Effect of stereotactic implantation of biodegradable 5-fluorouracil-loaded microspheres in healthy and C6 glioma-bearing rats. Menei, P., Boisdron-Celle, M., Croué, A., Guy, G., Benoit, J.P. Neurosurgery (1996) [Pubmed]
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