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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZNF239  -  zinc finger protein 239

Homo sapiens

Synonyms: HOK-2, HOK2, MOK2, Zinc finger protein 239, Zinc finger protein HOK-2, ...
 
 
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High impact information on ZNF239

  • Taken together, these results establish that the MOK2 proteins are able to recognize both DNA and RNA through their zinc fingers [1].
  • In this paper, we show that the MOK2 proteins are mainly associated with nuclear ribonucleoprotein components, including the nucleoli and extranucleolar structures, and exhibit specific RNA homopolymer binding activities [1].
  • The zinc finger transcription factor, MOK2, negatively modulates expression of the interphotoreceptor retinoid-binding protein gene, IRBP [2].
  • Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19 [3].
  • We have demonstrated that MOK2 can bind to the 8 bp present in the IRBP promoter and repress transcription from this promoter by competing with the CRX activator for DNA binding [4].
 

Anatomical context of ZNF239

  • The human and murine MOK2 ortholog genes that are preferentially expressed in brain and testis tissues encode two different Krüppel-like zinc finger proteins [1].
  • The deduced polypeptide shares 66% amino acid similarity with MOK-2, another protein of only zinc finger motifs and preferentially expressed in transformed cell lines [5].

References

  1. Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains. Arranz, V., Harper, F., Florentin, Y., Puvion, E., Kress, M., Ernoult-Lange, M. Mol. Cell. Biol. (1997) [Pubmed]
  2. The zinc finger transcription factor, MOK2, negatively modulates expression of the interphotoreceptor retinoid-binding protein gene, IRBP. Arranz, V., Dreuillet, C., Crisanti, P., Tillit, J., Kress, M., Ernoult-Lange, M. J. Biol. Chem. (2001) [Pubmed]
  3. Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19. Arranz, V., Kress, M., Ernoult-Lange, M. Mamm. Genome (1996) [Pubmed]
  4. In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C. Dreuillet, C., Tillit, J., Kress, M., Ernoult-Lange, M. Nucleic Acids Res. (2002) [Pubmed]
  5. A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. Rivolta, M.N., Negrini, C., Wilcox, E.R. Biochim. Biophys. Acta (1996) [Pubmed]
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