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Gene Review

Rbp3  -  retinol binding protein 3, interstitial

Mus musculus

Synonyms: IRBP, Interphotoreceptor retinoid-binding protein, Interstitial retinol-binding protein, Irbp, Rbp-3, ...
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Disease relevance of Rbp3


High impact information on Rbp3

  • Susceptibility to experimental autoimmune uveitis (EAU), a model for human uveitis induced in mice with the retinal antigen interphotoreceptor retinoid-binding protein (IRBP), is controlled by "natural" CD4(+)CD25(+) regulatory T (T reg) cells [5].
  • Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity [5].
  • In addition, lack of IRBP expression solely in the thymus, even in the presence of aire expression, is sufficient to trigger spontaneous eye-specific autoimmunity [6].
  • The KO mice had greatly elevated responses to IRBP, an altered recognition of IRBP epitopes, and their primed T cells induced exacerbated disease in WT recipients [7].
  • IRBP is believed to serve as a carrier for retinoids in the bleaching and regeneration cycle of rhodopsin [8].

Chemical compound and disease context of Rbp3


Biological context of Rbp3


Anatomical context of Rbp3


Associations of Rbp3 with chemical compounds

  • We determined during photoreceptor development if there is a retina-specific hypomethylation of the mouse gene encoding interphotoreceptor retinoid-binding protein (IRBP) that is associated with its activation [13].
  • Cells positive for both IRBP and BrdU were always observed as soon as 2 hr after injection but it took at least 40 hr before they became positive for both opsin and BrdU [13].
  • These results suggest that the regulation of IRBP by retinol is not transcriptional [8].
  • To understand the mechanism for this recovery, we determined whether vitamin A affects transcription and translation of the IRBP gene [8].
  • Wild-type and transgenic mice harboring the IRBP promoter-CAT reporter fusion gene were maintained on a retinol-deficient diet supplemented with retinoic acid (-A) or on a control diet (+A) for up to 60 wk postweaning [8].

Regulatory relationships of Rbp3


Other interactions of Rbp3

  • Rhodopsin and IRBP increased in parallel with ROS elongation up to P25, when the ROS had reached their mature lengths [15].
  • Second, the role of IRBP gene and protein expression in development was assessed by determining if their expression occurs before that of opsin [13].
  • Furthermore, we show that Mok2 expression in the developing mouse and in the adult retina seems to be concordant with IRBP expression [2].
  • Bilateral ocular and brain tumors ("trilateral") were found in three other SV40 T-ag transgenic murine lines containing different promoters (murine interphotoreceptor retinoid-binding protein (IRBP), human IRBP, and alpha A-crystallin) [4].
  • IRBP and RAG1 molecular clocks for Mus date the origin of subgenera to around 5-6 mya and the origin of Species Groups within subgenus Mus to around 2-3 mya [18].

Analytical, diagnostic and therapeutic context of Rbp3


  1. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Howes, K.A., Ransom, N., Papermaster, D.S., Lasudry, J.G., Albert, D.M., Windle, J.J. Genes Dev. (1994) [Pubmed]
  2. The zinc finger transcription factor, MOK2, negatively modulates expression of the interphotoreceptor retinoid-binding protein gene, IRBP. Arranz, V., Dreuillet, C., Crisanti, P., Tillit, J., Kress, M., Ernoult-Lange, M. J. Biol. Chem. (2001) [Pubmed]
  3. Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Xu, H., Wawrousek, E.F., Redmond, T.M., Nickerson, J.M., Wiggert, B., Chan, C.C., Caspi, R.R. Eur. J. Immunol. (2000) [Pubmed]
  4. Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen. Marcus, D.M., Lasudry, J.G., Carpenter, J.L., Windle, J., Howes, K.A., al-Ubaidi, M.R., Baehr, W., Overbeek, P.A., Font, R.L., Albert, D.M. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  5. Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. Grajewski, R.S., Silver, P.B., Agarwal, R.K., Su, S.B., Chan, C.C., Liou, G.I., Caspi, R.R. J. Exp. Med. (2006) [Pubmed]
  6. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. Devoss, J., Hou, Y., Johannes, K., Lu, W., Liou, G.I., Rinn, J., Chang, H., Caspi, R., Fong, L., Anderson, M.S. J. Exp. Med. (2006) [Pubmed]
  7. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. Avichezer, D., Grajewski, R.S., Chan, C.C., Mattapallil, M.J., Silver, P.B., Raber, J.A., Liou, G.I., Wiggert, B., Lewis, G.M., Donoso, L.A., Caspi, R.R. J. Exp. Med. (2003) [Pubmed]
  8. Visual sensitivity and interphotoreceptor retinoid binding protein in the mouse: regulation by vitamin A. Liou, G.I., Matragoon, S., Chen, D.M., Gao, C.L., Zhang, L., Fei, Y., Katz, M.L., Stark, W.S. FASEB J. (1998) [Pubmed]
  9. Delayed rhodopsin regeneration and altered distribution of interphotoreceptor retinoid binding protein (IRBP) in the mi(vit)/mi(vit) (vitiligo) mouse. Smith, S.B., McClung, J., Wiggert, B.N., Nir, I. J. Neurocytol. (1997) [Pubmed]
  10. Experimental autoimmune uveoretinitis in mice. Induction by a single eliciting event and dependence on quantitative parameters of immunization. Caspi, R.R., Chan, C.C., Leake, W.C., Higuchi, M., Wiggert, B., Chader, G.J. J. Autoimmun. (1990) [Pubmed]
  11. Murine experimental autoimmune uveoretinitis induced by interphotoreceptor retinoid-binding protein and Klebsiella pneumoniae 03 lipopolysaccharide (K03-LPS): a relation between H-2 haplotype and EAU induction. Ando, K., Yamamoto, J.H., Fujino, Y., Kato, N., Mochizuki, M. Graefes Arch. Clin. Exp. Ophthalmol. (1994) [Pubmed]
  12. Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor. Mishina, Y., Suzuki, A., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Ueno, N., Behringer, R.R. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  13. Timing of interphotoreceptor retinoid-binding protein (IRBP) gene expression and hypomethylation in developing mouse retina. Liou, G.I., Wang, M., Matragoon, S. Dev. Biol. (1994) [Pubmed]
  14. Localization of the gene for interphotoreceptor retinoid-binding protein to mouse chromosome 14 near Np-1. Danciger, M., Kozak, C.A., Nickerson, J., Redmond, T.M., Farber, D.B. Genomics (1990) [Pubmed]
  15. Rhodopsin, 11-cis vitamin A, and interstitial retinol-binding protein (IRBP) during retinal development in normal and rd mutant mice. Carter-Dawson, L., Alvarez, R.A., Fong, S.L., Liou, G.I., Sperling, H.G., Bridges, C.D. Dev. Biol. (1986) [Pubmed]
  16. A single cis-acting element in a short promoter segment of the gene encoding the interphotoreceptor retinoid-binding protein confers tissue-specific expression. Bobola, N., Hirsch, E., Albini, A., Altruda, F., Noonan, D., Ravazzolo, R. J. Biol. Chem. (1995) [Pubmed]
  17. Light deprivation profoundly affects gene expression of interphotoreceptor retinoid-binding protein in the mouse eye. Kutty, G., Duncan, T., Nickerson, J.M., Si, J.S., Van Veen, T., Chader, G.J., Wiggert, B. Exp. Eye Res. (1994) [Pubmed]
  18. Temporal, spatial, and ecological modes of evolution of Eurasian Mus based on mitochondrial and nuclear gene sequences. Suzuki, H., Shimada, T., Terashima, M., Tsuchiya, K., Aplin, K. Mol. Phylogenet. Evol. (2004) [Pubmed]
  19. Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. Liou, G.I., Fei, Y., Peachey, N.S., Matragoon, S., Wei, S., Blaner, W.S., Wang, Y., Liu, C., Gottesman, M.E., Ripps, H. J. Neurosci. (1998) [Pubmed]
  20. Albumin is not present in the murine interphotoreceptor matrix, or in that of transgenic mice lacking IRBP. Liao, R., Gonzalez-Fernandez, F. Mol. Vis. (2004) [Pubmed]
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