High impact information on MAX2

• ORE9, an F-box protein that regulates leaf senescence in Arabidopsis [1].
• The F-box motif of ORE9 interacts with ASK1 (Arabidopsis Skp1-like 1), a component of the plant SCF complex [1].
• Positional cloning identifies MAX2 as a member of the F-box leucine-rich repeat family of proteins [2].
• In this study, we demonstrate further conservation of the branching control system by showing that MAX2 and MAX3 are orthologous to RMS4 and RMS5, respectively [3].
• However, the ore9 mutation did not suppress edr1-mediated enhanced disease resistance to powdery mildew or spontaneous lesions, indicating that these phenotypes are controlled by separate signaling pathways [4].

Biological context of MAX2

• MAX2 is identical to ORE9, a proposed regulator of leaf senescence ( Woo, H. R., Chung, K. M., Park, J.-H., Oh, S. A., Ahn, T., Hong, S. H., Jang, S. K. and Nam, H. G. (2001) Plant Cell 13, 1779-1790) [2].
• Two edr1-associated phenotypes, drought-induced growth inhibition and ethylene-induced senescence, were suppressed by mutations in ORE9, implicating ubiquitin-mediated protein degradation in the regulation of these phenotypes [4].
• Map-based cloning of ORE9 identified a 693-amino acid polypeptide containing an F-box motif and 18 leucine-rich repeats [1].

Other interactions of MAX2

• These roles for MAX3, MAX4, and MAX2 are consistent with their known molecular identities [5].

References