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Gene Review

MAX2  -  F-box leucine-rich repeat family protein MAX2

Arabidopsis thaliana

Synonyms: F14N22.11, F14N22_11, MORE AXILLARY BRANCHES 2, ORE9, ORESARA 9, ...
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High impact information on MAX2

  • ORE9, an F-box protein that regulates leaf senescence in Arabidopsis [1].
  • The F-box motif of ORE9 interacts with ASK1 (Arabidopsis Skp1-like 1), a component of the plant SCF complex [1].
  • Positional cloning identifies MAX2 as a member of the F-box leucine-rich repeat family of proteins [2].
  • In this study, we demonstrate further conservation of the branching control system by showing that MAX2 and MAX3 are orthologous to RMS4 and RMS5, respectively [3].
  • However, the ore9 mutation did not suppress edr1-mediated enhanced disease resistance to powdery mildew or spontaneous lesions, indicating that these phenotypes are controlled by separate signaling pathways [4].

Biological context of MAX2

  • MAX2 is identical to ORE9, a proposed regulator of leaf senescence ( Woo, H. R., Chung, K. M., Park, J.-H., Oh, S. A., Ahn, T., Hong, S. H., Jang, S. K. and Nam, H. G. (2001) Plant Cell 13, 1779-1790) [2].
  • Two edr1-associated phenotypes, drought-induced growth inhibition and ethylene-induced senescence, were suppressed by mutations in ORE9, implicating ubiquitin-mediated protein degradation in the regulation of these phenotypes [4].
  • Map-based cloning of ORE9 identified a 693-amino acid polypeptide containing an F-box motif and 18 leucine-rich repeats [1].

Other interactions of MAX2

  • These roles for MAX3, MAX4, and MAX2 are consistent with their known molecular identities [5].


  1. ORE9, an F-box protein that regulates leaf senescence in Arabidopsis. Woo, H.R., Chung, K.M., Park, J.H., Oh, S.A., Ahn, T., Hong, S.H., Jang, S.K., Nam, H.G. Plant Cell (2001) [Pubmed]
  2. MAX1 and MAX2 control shoot lateral branching in Arabidopsis. Stirnberg, P., van De Sande, K., Leyser, H.M. Development (2002) [Pubmed]
  3. Branching Genes Are Conserved across Species. Genes Controlling a Novel Signal in Pea Are Coregulated by Other Long-Distance Signals. Johnson, X., Brcich, T., Dun, E.A., Goussot, M., Haurogn??, K., Beveridge, C.A., Rameau, C. Plant Physiol. (2006) [Pubmed]
  4. Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase. Tang, D., Christiansen, K.M., Innes, R.W. Plant Physiol. (2005) [Pubmed]
  5. MAX1 encodes a cytochrome P450 family member that acts downstream of MAX3/4 to produce a carotenoid-derived branch-inhibiting hormone. Booker, J., Sieberer, T., Wright, W., Williamson, L., Willett, B., Stirnberg, P., Turnbull, C., Srinivasan, M., Goddard, P., Leyser, O. Dev. Cell (2005) [Pubmed]
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