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Gene Review

EDR1  -  serine/threonine-protein kinase EDR1

Arabidopsis thaliana

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High impact information on EDR1

  • The edr1 mutation is recessive and maps to chromosome 1 between molecular markers ATEAT1 and NCC1 [1].
  • The EDR1 gene was isolated by positional cloning and was found to encode a putative MAP kinase kinase kinase similar to CTR1, a negative regulator of ethylene responses in Arabidopsis [2].
  • In contrast, the ein2 mutation did not suppress edr1-mediated resistance and associated phenotypes, indicating that ethylene and jasmonic acid-induced responses are not required for edr1 resistance [2].
  • Resistance mediated by the edr1 mutation is correlated with induction of several defense responses, including host cell death [2].
  • The NahG transgene, which lowers endogenous SA levels, also suppressed edr1 [2].

Biological context of EDR1


Anatomical context of EDR1

  • The EDR1 kinase domain displayed autophosphorylation activity and phosphorylated the common MAP kinase substrate myelin basic protein [4].

Other interactions of EDR1


Analytical, diagnostic and therapeutic context of EDR1

  • Molecular cloning and mRNA expression analysis of a novel rice (Oryzasativa L.) MAPK kinase kinase, OsEDR1, an ortholog of Arabidopsis AtEDR1, reveal its role in defense/stress signalling pathways and development [6].


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